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| Status |
Public on Jan 26, 2023 |
| Title |
Hedgehog signaling affects platelet-derived growth factor signaling mediated alveolar septum formation during postnatal lung development [bulk RNA-seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
HH inhibition reproduces the lung phenotype of PDGF pathway knockout lungs and results in profound effects on differentiation and gene expression of Pdgfra-expressing alveolar mesenchymal cells, in particular myofibroblasts.
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| Overall design |
Single cell lung suspensions of PgfraEGFP/+ reporter lungs (P8) from mice treated with anti-HH antibody 5E1 or control IgG at E18.5 were sorted based on endogenous EGFP fluorescence and were prepared for bulk RNA-seq.
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| |
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| Contributor(s) |
Kugler MC, Khodadadi-Jamayran A |
| Citation(s) |
36693140 |
| |
| Submission date |
Jun 27, 2022 |
| Last update date |
Apr 27, 2023 |
| Contact name |
Alireza Khodadadi-Jamayran |
| Organization name |
New York University, NYU Langone Medical Center
|
| Department |
Division of Advanced Research Technologies (DART)
|
| Lab |
Applied Bioinformatics Laboratories (ABL)
|
| Street address |
550 1st Ave, MSB 304
|
| City |
New York City |
| State/province |
NY |
| ZIP/Postal code |
10016 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE207062 |
Hedgehog and PDGF signaling intersect during postnatal lung development |
|
| Relations |
| BioProject |
PRJNA853371 |
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