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| Status |
Public on Feb 06, 2023 |
| Title |
Transcriptome sequencing (RNA-Seq) of liver tissues from LXRα-/- mices and wild type mices fed with a chow diet or a high fat diet (HFD). |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Liver X receptor α (LXRα） is a key regulator of lipid homeostasis and effective inhibitors of inflammation. We used the second-generation transcriptome sequencing(RNA-seq) to determine the expression changes of each gene in LXRα-/- mices and wild type mices fed with a chow diet or a high fat diet (HFD).We investigated the downstream molecular mechanisms by which loss of LXRα regulates lipid synthesis and metabolism in HFD.
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| Overall design |
mRNA profiles were obtained from mice livers which were divided into 4 group: WT Chow, LXRα-/- Chow, WT HFD and LXRα-/- HFD.
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| |
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| Contributor(s) |
Tang L, Chen Y |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
May 27, 2022 |
| Last update date |
Feb 06, 2023 |
| Contact name |
Lan Tang |
| E-mail(s) |
tl405@smu.edu.cn
|
| Phone |
+86 20 61648596
|
| Organization name |
Southern Medical University
|
| Department |
School of Pharmaceutical Science
|
| Lab |
Biopharmaceutics
|
| Street address |
1838 Guangzhou North Ave,
|
| City |
Guangzhou |
| State/province |
Guangdong |
| ZIP/Postal code |
510515 |
| Country |
China |
| |
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| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
|
| Samples (20)
|
| GSM6203749 |
WT Chow，replicate4 |
| GSM6203750 |
WT Chow，replicate5 |
| GSM6203751 |
WT HFD, replicate1 |
| GSM6203752 |
WT HFD, replicate2 |
| GSM6203753 |
WT HFD, replicate3 |
| GSM6203754 |
WT HFD, replicate4 |
| GSM6203755 |
WT HFD, replicate5 |
| GSM6203756 |
LXRα-/- Chow, replicate1 |
| GSM6203757 |
LXRα-/- Chow, replicate2 |
| GSM6203758 |
LXRα-/- Chow, replicate3 |
| GSM6203759 |
LXRα-/- Chow, replicate4 |
| GSM6203760 |
LXRα-/- Chow, replicate5 |
| GSM6203761 |
LXRα-/- HFD, replicate1 |
| GSM6203762 |
LXRα-/- HFD, replicate2 |
| GSM6203763 |
LXRα-/- HFD, replicate3 |
| GSM6203764 |
LXRα-/- HFD, replicate4 |
| GSM6203765 |
LXRα-/- HFD, replicate5 |
|
| Relations |
| BioProject |
PRJNA843027 |
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