GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE204986 Query DataSets for GSE204986
Status Public on Feb 06, 2023
Title Transcriptome sequencing (RNA-Seq) of liver tissues from LXRα-/- mices and wild type mices fed with a chow diet or a high fat diet (HFD).
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Liver X receptor α (LXRα) is a key regulator of lipid homeostasis and effective inhibitors of inflammation. We used the second-generation transcriptome sequencing(RNA-seq) to determine the expression changes of each gene in LXRα-/- mices and wild type mices fed with a chow diet or a high fat diet (HFD).We investigated the downstream molecular mechanisms by which loss of LXRα regulates lipid synthesis and metabolism in HFD.
Overall design mRNA profiles were obtained from mice livers which were divided into 4 group: WT Chow, LXRα-/- Chow, WT HFD and LXRα-/- HFD.
Contributor(s) Tang L, Chen Y
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date May 27, 2022
Last update date Feb 06, 2023
Contact name Lan Tang
Phone +86 20 61648596
Organization name Southern Medical University
Department School of Pharmaceutical Science
Lab Biopharmaceutics
Street address 1838 Guangzhou North Ave,
City Guangzhou
State/province Guangdong
ZIP/Postal code 510515
Country China
Platforms (1)
GPL21103 Illumina HiSeq 4000 (Mus musculus)
Samples (20)
GSM6203746 WT Chow,replicate1
GSM6203747 WT Chow,replicate2
GSM6203748 WT Chow,replicate3
BioProject PRJNA843027

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE204986_genes_fpkm_expression.xlsx 24.0 Mb (ftp)(http) XLSX
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap