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| Status |
Public on May 16, 2022 |
| Title |
Effect of cardiomyocyte-specific deletion of glucocorticoid receptor on gene expression of cultured neonatal cardiomyocytes |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To investigate the role of the glucocorticoid receptor (GR) in the regulation of cardiomyocyte maturation and proliferation, we established a cardiomyocyte-specific GR knock-out (GR-cKO) mouse model by Cre-Lox technology. We thus performed gene expression profiling analysis using data obtained from RNA-seq of cardiomyocytes isolated from GR-cKO and control mouse models at neonatal stage and cultured in vitro. Our analyses unveiled a role for GR in regulating gene networks related to the energetic metabolism, which in turn may impact on cardiomyocyte proliferative and regenerative ability.
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| Overall design |
Comparative gene expression profiling analysis of RNA-seq data of cardiomyocytes isolated from GR-cKO and control mouse models at postnatal-day-1 (P1) and cultured in vitro
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| Contributor(s) |
D'Uva G |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
May 13, 2022 |
| Last update date |
May 18, 2022 |
| Contact name |
Gabriele D'Uva |
| E-mail(s) |
gabrielematteo.duva2@unibo.it
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| Organization name |
University of Bologna
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| Street address |
via Massarenti 9
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| City |
Bologna |
| ZIP/Postal code |
40138 |
| Country |
Italy |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE203021 |
Effect of glucocorticoid receptor deletion on gene expression of cardiomyocytes at neonatal and early postnatal stages |
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| Relations |
| BioProject |
PRJNA837897 |
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