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| Status |
Public on Jun 27, 2022 |
| Title |
Identification of a shared disease-associated oligodendrocyte signature among multiple CNS pathologies |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The role of oligodendrocytes in Alzheimer’s disease (AD) has never been fully elucidated. To dissect their possible contribution to the disease we perform single-cell RNA-sequencing (scRNA-seq) on the brains of healthy and 5XFaD (genetic model of AD) at different ages.
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| Overall design |
We performed massively parallel single-cell RNA sequencing (MARS-seq2.0) on non-immune cells (CD45-) or specifically on oligodendrocytes (GalC+) from brains of WT and 5XFaD mice.
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| Web link |
https://doi.org/10.1038/s41593-022-01104-7
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| Contributor(s) |
Kenigsbuch M, Bost P |
| Citation(s) |
35760863 |
| |
| Submission date |
May 05, 2022 |
| Last update date |
Sep 28, 2022 |
| Contact name |
Ido Amit |
| E-mail(s) |
ido.amit@weizmann.ac.il
|
| Phone |
972-8-9343338
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| Organization name |
Weizmann Institute of Science
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| Department |
Immunology
|
| Street address |
234 Herzl st.
|
| City |
Rehovot |
| ZIP/Postal code |
760001 |
| Country |
Israel |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (95)
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| Relations |
| BioProject |
PRJNA835412 |
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