|
| Status |
Public on Sep 14, 2023 |
| Title |
Lysine methylation of EHMT1/GLP as a molecular switch to reprogram transcription networks in prostate cancer [RNA-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Our studies provide novel molecular insights into the activity and function of EHMT1 during PCa progression and suggest a novel therapeutic strategy to treat CRPC with EHMT1 inhibitors.
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| |
|
| Overall design |
LNCaP-tet-EHMT1 cells were treated with/out 0.25ug/mL doxycycline for two days. LNCaP cells were treated with siNTC, siEHMT1 at 20nM for two days. All RNA-seq samples contain replications.
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| |
|
| Contributor(s) |
Besschetnova A, Han W, Liu M, Han D, Cai C |
| Citation(s) |
37663929 |
| |
| Submission date |
Apr 28, 2022 |
| Last update date |
Sep 14, 2023 |
| Contact name |
Changmeng Cai |
| E-mail(s) |
changmeng.cai@umb.edu
|
| Organization name |
University of Massachusetts Boston
|
| Street address |
100 William T Morrissey Blvd
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02125 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (20)
|
| GSM6071085 |
siEHMT1-rep 2 |
| GSM6071086 |
EHMT1-WT, Veh-rep 1 |
| GSM6071087 |
EHMT1-WT, Veh-rep 2 |
| GSM6071088 |
EHMT1-WT, Dox-rep 1 |
| GSM6071089 |
EHMT1-WT, Dox-rep 2 |
| GSM6071090 |
EHMT1-K450R, Veh-rep 1 |
| GSM6071091 |
EHMT1-K450R, Veh-rep 2 |
| GSM6071092 |
EHMT1-K450R, Dox-rep 1 |
| GSM6071093 |
EHMT1-K450R, Dox-rep 2 |
| GSM6071094 |
EHMT1-K451R, Veh-rep 1 |
| GSM6071095 |
EHMT1-K451R, Veh-rep 2 |
| GSM6071096 |
EHMT1-K451R, Dox-rep 1 |
| GSM6071097 |
EHMT1-K451R, Dox-rep 2 |
| GSM6071098 |
EHMT1-K450RK451R, Veh-rep 1 |
| GSM6071099 |
EHMT1-K450RK451R, Veh-rep 2 |
| GSM6071100 |
EHMT1-K450RK451R, Dox-rep 1 |
| GSM6071101 |
EHMT1-K450RK451R, Dox-rep 2 |
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| This SubSeries is part of SuperSeries: |
| GSE201771 |
Lysine methylation of EHMT1/GLP as a molecular switch to reprogram transcription networks in prostate cancer |
|
| Relations |
| BioProject |
PRJNA832968 |
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