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Status |
Public on Apr 24, 2022 |
Title |
BAF complex cooperates with c-Myc to orchestrate early fate decisions of CD8 T cells (ATAC III) |
Organism |
Mus musculus |
Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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Summary |
We found cBAF and c-Myc co-assort asymmetrically to the two daughter nuclei, such that daughter cells with low c-Myc and cBAF display a cell fate trajectory towards memory T cell differentiation. Moreover, cBAF complex and c-Myc physically interact with each other, and act in establishing the chromatin landscape in activated CD8 T cells.
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Overall design |
ATAC-seq analysis of 9 samples: Activated WT CD8 T cells (n=3), Activated Arid1a KO CD8 T cells (n=3), Activated WT CD8 T cells treated with Arid1a inhibitor (n=3).
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Contributor(s) |
Guo A, Huang H, Chen MJ, Chi H, Green DR |
Citation(s) |
35732731 |
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Submission date |
Mar 17, 2022 |
Last update date |
Jul 08, 2022 |
Contact name |
Douglas R Green |
E-mail(s) |
douglas.green@stjude.org
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Organization name |
St Jude Children's Research Hospital
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Department |
Immunology
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Lab |
Green lab
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Street address |
262 Danny Thomas Pl
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City |
Memphis |
State/province |
United States |
ZIP/Postal code |
38105 |
Country |
USA |
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Platforms (1) |
GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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Samples (9)
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GSM5959116 |
BRD-K98645985-treated ATAC-seq replicate 1 |
GSM5959117 |
BRD-K98645985-treated ATAC-seq replicate 2 |
GSM5959118 |
BRD-K98645985-treated ATAC-seq replicate 3 |
GSM5959119 |
DMSO-treated Arid1a KO ATAC-seq replicate 1 |
GSM5959120 |
DMSO-treated Arid1a KO ATAC-seq replicate 2 |
GSM5959121 |
DMSO-treated Arid1a KO ATAC-seq replicate 3 |
GSM5959122 |
DMSO-treated WT ATAC-seq replicate 1 |
GSM5959123 |
DMSO-treated WT ATAC-seq replicate 2 |
GSM5959124 |
DMSO-treated WT ATAC-seq replicate 3 |
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This SubSeries is part of SuperSeries: |
GSE183619 |
BAF complex cooperates with c-Myc to orchestrate early fate decisions of CD8 T cells |
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Relations |
BioProject |
PRJNA817256 |