|
| Status |
Public on Apr 24, 2022 |
| Title |
BAF complex cooperates with c-Myc to orchestrate early fate decisions of CD8 T cells (ATAC III) |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We found cBAF and c-Myc co-assort asymmetrically to the two daughter nuclei, such that daughter cells with low c-Myc and cBAF display a cell fate trajectory towards memory T cell differentiation. Moreover, cBAF complex and c-Myc physically interact with each other, and act in establishing the chromatin landscape in activated CD8 T cells.
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| |
|
| Overall design |
ATAC-seq analysis of 9 samples: Activated WT CD8 T cells (n=3), Activated Arid1a KO CD8 T cells (n=3), Activated WT CD8 T cells treated with Arid1a inhibitor (n=3).
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| |
|
| Contributor(s) |
Guo A, Huang H, Chen MJ, Chi H, Green DR |
| Citation(s) |
35732731 |
| |
| Submission date |
Mar 17, 2022 |
| Last update date |
Jul 08, 2022 |
| Contact name |
Douglas R Green |
| E-mail(s) |
douglas.green@stjude.org
|
| Organization name |
St Jude Children's Research Hospital
|
| Department |
Immunology
|
| Lab |
Green lab
|
| Street address |
262 Danny Thomas Pl
|
| City |
Memphis |
| State/province |
United States |
| ZIP/Postal code |
38105 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
|
| Samples (9)
|
| GSM5959116 |
BRD-K98645985-treated ATAC-seq replicate 1 |
| GSM5959117 |
BRD-K98645985-treated ATAC-seq replicate 2 |
| GSM5959118 |
BRD-K98645985-treated ATAC-seq replicate 3 |
| GSM5959119 |
DMSO-treated Arid1a KO ATAC-seq replicate 1 |
| GSM5959120 |
DMSO-treated Arid1a KO ATAC-seq replicate 2 |
| GSM5959121 |
DMSO-treated Arid1a KO ATAC-seq replicate 3 |
| GSM5959122 |
DMSO-treated WT ATAC-seq replicate 1 |
| GSM5959123 |
DMSO-treated WT ATAC-seq replicate 2 |
| GSM5959124 |
DMSO-treated WT ATAC-seq replicate 3 |
|
| This SubSeries is part of SuperSeries: |
| GSE183619 |
BAF complex cooperates with c-Myc to orchestrate early fate decisions of CD8 T cells |
|
| Relations |
| BioProject |
PRJNA817256 |
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