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| Status |
Public on Oct 06, 2022 |
| Title |
Single-cell RNA sequencing reveals the impact of CD34+ cells in heart failure |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
CD34+ cells have been used to treat the patients with heart failure, but the outcome is variable. It is of great significance to scrutinize the fate and the mechanism of CD34+ cell differentiation in vivo during heart failure and explore its intervention strategy. By analyzing the transcriptomes of single cells from the Cd34-CreERT2;R26-tdTomato heart, we illustrated the dynamics of cell landscape during the progression of heart hypertrophy, including CD34+ cells, fibroblasts, endothelial cells and immune cells. And Our study also provides a cellular landscape of CD34+ cell-derived cells in the hypertrophy heart of animal models.
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| |
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| Overall design |
scRNA-seq for total non-cardiomyocytes and CD34+ cells from Cd34-CreERT2;R26-tdTomato mice hearts
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| Contributor(s) |
Du L, SUN X, Xu Q |
| Citation(s) |
36805782 |
| Submission date |
Mar 17, 2022 |
| Last update date |
Mar 08, 2023 |
| Contact name |
Qingbo Xu |
| E-mail(s) |
qingbo_xu@zju.edu.cn
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| Organization name |
First Affiliated Hospital, Zhejiang University School of Medicine
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| Department |
Department of Cardiology
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| Street address |
79 Qingchun Road
|
| City |
Hangzhou |
| State/province |
Zhejiang |
| ZIP/Postal code |
310003 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (7)
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| Relations |
| BioProject |
PRJNA817182 |
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