|
| Status |
Public on Apr 19, 2022 |
| Title |
Molecular landscape of immature neurons in the human hippocampus in Alzheimer's disease |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Molecular landscape of immature neurons in the human hippocampus in Alzheimer's disease
|
| |
|
| Overall design |
Immature dentate granule cells (imGCs) arising from adult hippocampal neurogenesis contribute to plasticity and unique brain functions in rodents and they are dysregulated in many human neurological disorders. Little is known about molecular characteristics of adult human hippocampal imGCs and even their existence is under debate. Here we performed single nucleus RNA-sequencing (snRNA-seq) aided by a validated machine learning-based analytic approach to identify imGCs in both Alzheimer's disease and control and found a decreased number of imGCs with altered gene expression in AD.
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| |
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| Contributor(s) |
Su Y, Zhou Y, Song H, Ming G |
| Citation(s) |
35794479 |
| |
| Submission date |
Mar 10, 2022 |
| Last update date |
Jul 19, 2022 |
| Contact name |
Yijing Su |
| E-mail(s) |
yijingsu@upenn.edu
|
| Phone |
4438386479
|
| Organization name |
University of Pennsylvania
|
| Department |
Department of Oral Medicine
|
| Street address |
Levy 326
|
| City |
Philadelphia |
| State/province |
PA |
| ZIP/Postal code |
19428 |
| Country |
USA |
| |
|
| Platforms (1) |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA814627 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE198323_Sample23_lib1.barcode.txt.gz |
12.1 Kb |
(ftp)(http) |
TXT |
| GSE198323_Sample23_lib1.txt.gz |
4.0 Mb |
(ftp)(http) |
TXT |
| GSE198323_Sample23_lib2.barcode.txt.gz |
13.2 Kb |
(ftp)(http) |
TXT |
| GSE198323_Sample23_lib2.txt.gz |
4.4 Mb |
(ftp)(http) |
TXT |
| GSE198323_Sample24_lib1.barcode.txt.gz |
10.1 Kb |
(ftp)(http) |
TXT |
| GSE198323_Sample24_lib1.txt.gz |
2.9 Mb |
(ftp)(http) |
TXT |
| GSE198323_Sample24_lib2.barcode.txt.gz |
10.5 Kb |
(ftp)(http) |
TXT |
| GSE198323_Sample24_lib2.txt.gz |
2.6 Mb |
(ftp)(http) |
TXT |
| GSE198323_Sample25_lib1.barcode.txt.gz |
10.1 Kb |
(ftp)(http) |
TXT |
| GSE198323_Sample25_lib1.txt.gz |
2.7 Mb |
(ftp)(http) |
TXT |
| GSE198323_Sample25_lib2.barcode.txt.gz |
10.6 Kb |
(ftp)(http) |
TXT |
| GSE198323_Sample25_lib2.txt.gz |
2.6 Mb |
(ftp)(http) |
TXT |
| GSE198323_Sample26.barcode.txt.gz |
13.2 Kb |
(ftp)(http) |
TXT |
| GSE198323_Sample26.txt.gz |
4.4 Mb |
(ftp)(http) |
TXT |
| GSE198323_Sample27.barcode.txt.gz |
15.1 Kb |
(ftp)(http) |
TXT |
| GSE198323_Sample27.txt.gz |
4.3 Mb |
(ftp)(http) |
TXT |
| GSE198323_Sample28.barcode.txt.gz |
14.7 Kb |
(ftp)(http) |
TXT |
| GSE198323_Sample28.txt.gz |
4.2 Mb |
(ftp)(http) |
TXT |
| GSE198323_Sample29_lib1.barcode.txt.gz |
14.3 Kb |
(ftp)(http) |
TXT |
| GSE198323_Sample29_lib1.txt.gz |
3.7 Mb |
(ftp)(http) |
TXT |
| GSE198323_Sample29_lib2.barcode.txt.gz |
15.1 Kb |
(ftp)(http) |
TXT |
| GSE198323_Sample29_lib2.txt.gz |
4.3 Mb |
(ftp)(http) |
TXT |
| GSE198323_Sample30_lib1.barcode.txt.gz |
10.0 Kb |
(ftp)(http) |
TXT |
| GSE198323_Sample30_lib1.txt.gz |
3.0 Mb |
(ftp)(http) |
TXT |
| GSE198323_Sample30_lib2.barcode.txt.gz |
9.9 Kb |
(ftp)(http) |
TXT |
| GSE198323_Sample30_lib2.txt.gz |
3.0 Mb |
(ftp)(http) |
TXT |
| GSE198323_Sample31_lib1.barcode.txt.gz |
15.2 Kb |
(ftp)(http) |
TXT |
| GSE198323_Sample31_lib1.txt.gz |
5.2 Mb |
(ftp)(http) |
TXT |
| GSE198323_Sample31_lib2.barcode.txt.gz |
14.1 Kb |
(ftp)(http) |
TXT |
| GSE198323_Sample31_lib2.txt.gz |
4.8 Mb |
(ftp)(http) |
TXT |
| GSE198323_Sample32_lib1.barcode.txt.gz |
13.7 Kb |
(ftp)(http) |
TXT |
| GSE198323_Sample32_lib1.txt.gz |
3.5 Mb |
(ftp)(http) |
TXT |
| GSE198323_Sample32_lib2.barcode.txt.gz |
14.7 Kb |
(ftp)(http) |
TXT |
| GSE198323_Sample32_lib2.txt.gz |
4.2 Mb |
(ftp)(http) |
TXT |
| GSE198323_Sample33_lib1.barcode.txt.gz |
15.5 Kb |
(ftp)(http) |
TXT |
| GSE198323_Sample33_lib1.txt.gz |
5.2 Mb |
(ftp)(http) |
TXT |
| GSE198323_Sample33_lib2.barcode.txt.gz |
14.5 Kb |
(ftp)(http) |
TXT |
| GSE198323_Sample33_lib2.txt.gz |
4.8 Mb |
(ftp)(http) |
TXT |
| GSE198323_Sample34_lib1.barcode.txt.gz |
9.0 Kb |
(ftp)(http) |
TXT |
| GSE198323_Sample34_lib1.txt.gz |
5.2 Mb |
(ftp)(http) |
TXT |
| GSE198323_Sample34_lib2.barcode.txt.gz |
9.7 Kb |
(ftp)(http) |
TXT |
| GSE198323_Sample34_lib2.txt.gz |
4.6 Mb |
(ftp)(http) |
TXT |
| GSE198323_Sample35.barcode.txt.gz |
38.7 Kb |
(ftp)(http) |
TXT |
| GSE198323_Sample35.txt.gz |
6.5 Mb |
(ftp)(http) |
TXT |
| GSE198323_Sample36.barcode.txt.gz |
11.1 Kb |
(ftp)(http) |
TXT |
| GSE198323_Sample36.txt.gz |
3.6 Mb |
(ftp)(http) |
TXT |
| GSE198323_Sample37_lib1.barcode.txt.gz |
9.8 Kb |
(ftp)(http) |
TXT |
| GSE198323_Sample37_lib1.txt.gz |
2.8 Mb |
(ftp)(http) |
TXT |
| GSE198323_Sample37_lib2.barcode.txt.gz |
9.9 Kb |
(ftp)(http) |
TXT |
| GSE198323_Sample37_lib2.txt.gz |
2.9 Mb |
(ftp)(http) |
TXT |
| GSE198323_Sample38.barcode.txt.gz |
16.5 Kb |
(ftp)(http) |
TXT |
| GSE198323_Sample38.txt.gz |
6.5 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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