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| Status |
Public on May 15, 2023 |
| Title |
UHRF1 is a mediator of KRAS driven oncogenesis in lung adenocarcinoma [RNA-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
RNA sequening was performed to understand the role of UHRF1 in regulation of gene expression in KRAS mutant lung cancer cell lines. Knock-down of both UHRF1 and KRAS leads to significant and overlapping changes in gene expression in both cell lines.
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| |
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| Overall design |
Two KRAS mutant lung cancer cell lines were used (A549, H358). Each cell line was treated with control siRNA (siNeg), anti-KRAS siRNA (siKRAS) or anti-UHRF1 siRNA (siUHRF1) in 3 biological replicates.
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| |
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| Contributor(s) |
Kaja K, Alejandro S, Alex L |
| Citation(s) |
37407562 |
| |
| Submission date |
Mar 10, 2022 |
| Last update date |
Jul 14, 2023 |
| Contact name |
Alex G Lee |
| E-mail(s) |
Alex.Lee2@ucsf.edu
|
| Phone |
6508987331
|
| Organization name |
UCSF
|
| Street address |
1550 4th Street
|
| City |
San Francisco |
| State/province |
CA |
| ZIP/Postal code |
94158 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (18)
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| This SubSeries is part of SuperSeries: |
| GSE198450 |
UHRF1 is a mediator of KRAS driven oncogenesis in lung adenocarcinoma |
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| Relations |
| BioProject |
PRJNA814495 |
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