|
| Status |
Public on Apr 06, 2010 |
| Title |
Oncogenic Functions of the Transcription Factor LSF |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Overexpression of LSF in less aggressive hepatocellular carcinoma (HCC) cells resulted in highly aggressive, angiogenic and multi-organ metastatic tumors while inhibition of LSF significantly abrogated growth and metastasis of highly aggressive HCC cells in nude mice.
We used microarrays to identify the downstream genes mediating the effects of LSF in HCC cells.
|
| |
|
| Overall design |
Gene expression profiles were compared between Control-8 and LSF-17 clones of HepG3 cells.
|
| |
|
| Contributor(s) |
Sarkar D, Dumur CI |
| Citation(s) |
20404171 |
| |
| Submission date |
Jan 08, 2010 |
| Last update date |
Dec 06, 2018 |
| Contact name |
Devanand Sarkar |
| E-mail(s) |
dsarkar@vcu.edu
|
| Organization name |
Virginia Commonwealth University
|
| Department |
Department of Human and Molecular Genetics
|
| Lab |
VCU Institute of Molecular Medicine
|
| Street address |
1220 E Broad St, Room 7044
|
| City |
Richmond |
| State/province |
VA |
| ZIP/Postal code |
23298 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL571 |
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA122087 |
Less...
More...