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| Status |
Public on Jul 01, 2022 |
| Title |
Glucagon-like Peptide-1 (GLP-1) Rescue Diabetic Cardiac Dysfuntions in Human iPSC-Derived Cardiomyocytes |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We investigate the effects of GLP-1 on diabetic cardiomyocytes (DCMs) model established by human induced pluripotent stem cells-derived cardiomyocytes (iPSC-CMs). Two subtypes of GLP-1, GLP-17-36 and GLP-19-36, were evaluated for their efficacy on hypertrophic phenotype, impaired calcium homeostasis and electrophysiological properties. RNA-seq was performed to reveal the underlying molecular mechanism of GLP-1. Our results demonstrated that GLP-17-36 and GLP-19-36 were able to ameliorate high glucose-induced hypertrophy phenotype and cardiac dysfunctions in DCM model based on iPSC-CMs. Our study provides a novel platform to unveil the cellular mechanisms of diabetic cardiomyopathy, which sheds light on discovering better targets for novel therapeutic interventions.
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| Overall design |
CM control group ( iPSC-CMs,n=4 ), DCM model group (diabetic cardiomyocytes,n=4), GLP-17-36 treatment group (diabetic cardiomyocytes treated with GLP-17-36,n=4), GLP-19-36 treatment group (diabetic cardiomyocytes treated with GLP-19-36,n=4)
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| Contributor(s) |
Zhou Y, Liu Y, Wang J, Qiao Y |
| Citation(s) |
36373695 |
| |
| Submission date |
Mar 03, 2022 |
| Last update date |
Jul 07, 2025 |
| Contact name |
Ying Zhou |
| E-mail(s) |
zhoying916@stu.njmu.edu.cn
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| Phone |
86-15895916398
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| Organization name |
Nanjing Medical university
|
| Street address |
101 longmian street
|
| City |
nanjing |
| ZIP/Postal code |
211166 |
| Country |
China |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA812513 |
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