|
| Status |
Public on Jul 01, 2022 |
| Title |
Glucagon-like Peptide-1 (GLP-1) Rescue Diabetic Cardiac Dysfuntions in Human iPSC-Derived Cardiomyocytes |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We investigate the effects of GLP-1 on diabetic cardiomyocytes (DCMs) model established by human induced pluripotent stem cells-derived cardiomyocytes (iPSC-CMs). Two subtypes of GLP-1, GLP-17-36 and GLP-19-36, were evaluated for their efficacy on hypertrophic phenotype, impaired calcium homeostasis and electrophysiological properties. RNA-seq was performed to reveal the underlying molecular mechanism of GLP-1. Our results demonstrated that GLP-17-36 and GLP-19-36 were able to ameliorate high glucose-induced hypertrophy phenotype and cardiac dysfunctions in DCM model based on iPSC-CMs. Our study provides a novel platform to unveil the cellular mechanisms of diabetic cardiomyopathy, which sheds light on discovering better targets for novel therapeutic interventions.
|
| |
|
| Overall design |
CM control group ( iPSC-CMs,n=4 ), DCM model group (diabetic cardiomyocytes,n=4), GLP-17-36 treatment group (diabetic cardiomyocytes treated with GLP-17-36,n=4), GLP-19-36 treatment group (diabetic cardiomyocytes treated with GLP-19-36,n=4)
|
| |
|
| Contributor(s) |
Zhou Y, Liu Y, Wang J, Qiao Y |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Mar 03, 2022 |
| Last update date |
Jul 01, 2022 |
| Contact name |
Ying Zhou |
| E-mail(s) |
zhoying916@stu.njmu.edu.cn
|
| Phone |
86-15895916398
|
| Organization name |
Nanjing Medical university
|
| Street address |
101 longmian street
|
| City |
nanjing |
| ZIP/Postal code |
211166 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
|
| Samples (16)
|
|
| Relations |
| BioProject |
PRJNA812513 |
Less...
More...