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Series GSE19709 Query DataSets for GSE19709
Status Public on Dec 30, 2011
Title Transcriptional Response of Adult Mouse Brain to Hypoxia
Organism Mus musculus
Experiment type Expression profiling by array
Summary Since normal brain function depends upon continuous oxygen delivery and short periods of hypoxia can precondition against subsequent ischemia, this study examined the effects of brief hypoxia on the whole genome transcriptional response in adult mouse brain.
Genomic expression profiling was perfromed for individual brain regions of the adult mice following the entire time course of hypoxia preconditioning.
Overall design Adult C57BL/6 male mice were exposed to systemic preconditioning hypoxia (8% O2 ) for 3 hr and allowed to recover in normoxia for 24 hr. The mouse brains were removed and dissected into individual brain regions at multiple time points during the 3hr hypoxia and subsequent 24hr reoxygenation periods. Total RNA was purified from the human whole blood or individual mouse brain regions. Genomic scale gene expression was then measured with Affymetrix Mouse Expression 430 2.0 arrays.
Contributor(s) Xu H, Lu A, Sharp FR
Citation(s) 21988864
Submission date Dec 30, 2009
Last update date Feb 11, 2019
Contact name Huichun Xu
Organization name University of California at Davis
Street address 2805 50th Street
City Sacramento
State/province CA
ZIP/Postal code 95817
Country USA
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (168)
GSM491761 mouse_cerebellum_time_point_0hr_replicate1
GSM491762 mouse_cerebellum_time_point_hypoxia_1hr_replicate1
GSM491763 mouse_cerebellum_time_point_hypoxia_3hr_replicate1
BioProject PRJNA121897

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Supplementary file Size Download File type/resource
GSE19709_RAW.tar 736.8 Mb (http)(custom) TAR (of CEL, CHP)
Raw data provided as supplementary file
Processed data included within Sample table
Processed data provided as supplementary file

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