|
| Status |
Public on Jul 05, 2022 |
| Title |
The central clock suffices to drive the majority of circulatory metabolic rhythms |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
This dataset was generated to investigate the independence of the central clock in regulating hepatic transcriptional rhythms.
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| |
|
| Overall design |
The core clock gene Bmal1 was knocked out using a floxed STOP codon (KO mice). By crossing these mice with Syt10-Cre mice we were able to rescue the Bmal1 expression in the suprachiasmatic nucleus (RE mice). These mice were compared with mice expressing Bmal1 in all tissues (WT). Livers were collected at 6 time points over the circadian 24-hour period.
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| |
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| Contributor(s) |
Petrus P, Chen S, Baldi P |
| Citation(s) |
35767612 |
| |
| Submission date |
Feb 09, 2022 |
| Last update date |
Jul 05, 2022 |
| Contact name |
Siwei Chen |
| E-mail(s) |
siweic@uci.edu
|
| Organization name |
University of California, Irvine
|
| Department |
Computer Science
|
| Lab |
Pierre Baldi
|
| Street address |
66304 Verano Road South
|
| City |
irvine |
| State/province |
CA |
| ZIP/Postal code |
92617 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
|
| Samples (54)
|
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| Relations |
| BioProject |
PRJNA804883 |
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