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| Status |
Public on Aug 22, 2022 |
| Title |
Allele-specific differential regulation of monoallelically expressed autosomal genes in the cardiac lineage [CUT&Tag] |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
We reported the allele-specific single cell RNA sequencing in highly morphogenic (C57Bl6J-maternal x CASTEiJ-paternal) male F1 mouse embryonic stem cells (mESC) and in vitro mESC derived six cardiac lineage cell types. We demonstrated distinctive gene regulation based on the parental origin of the alleles. We showed that deterministic and stochastic monoalleleic gene classes are distinctive in regulation and are involved in unique processes. In this study we highlighted the importance of parental origin-specific gene expression in development, homeostasis and disease.
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| Overall design |
Examination of allele-specific histone signatures in F1 mESCs.
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| Contributor(s) |
Balasooriya GI, Spector DL |
| Citation(s) |
36216821 |
| |
| Submission date |
Feb 01, 2022 |
| Last update date |
Dec 06, 2022 |
| Contact name |
Gayan Indhu Balasooriya |
| E-mail(s) |
gbalasoo@cshl.edu
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| Organization name |
Cold Spring Harbor Laboratory
|
| Street address |
1 Bungtown Road
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| City |
Cold Spring Harbor |
| ZIP/Postal code |
11724 |
| Country |
USA |
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| Platforms (1) |
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| Samples (7)
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| This SubSeries is part of SuperSeries: |
| GSE173403 |
Allele-specific differential regulation of monoallelically expressed autosomal genes in the cardiac lineage |
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| Relations |
| BioProject |
PRJNA802532 |
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