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| Status |
Public on Oct 13, 2022 |
| Title |
Spatial transcriptomics reveal unnresolved wound repair as potential driver of PFA Ependymoma progression |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Childhood brain tumor ependymoma remains incurable in approximately 50 percent of cases. No oncogenic mechanism has been firmly established for the commonest ependymoma variant posterior fossa subgroup A (PFA), impeding clinical advances. Uncovering how heterogeneous cell types within the tumor microenvironment interact is crucial to a complete understanding of PFA disease progression. The underlying cellular components of the PFA tumor microenvironment have been revealed by single cell transcriptomics, identifying divergent epithelial differentiation and EMT lineages. Here we utilize spatial transcriptomics (Visium) of 14 PFA samples to chart neoplastic and immune cell architecture and identify novel biological processes.
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| |
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| Overall design |
spatial transcriptomics (Visium) of 14 PFA samples
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| |
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| Contributor(s) |
Fu R, Norris G, Willard N, Foreman N, Donson A |
| Citation(s) |
36215273 |
| Submission date |
Jan 28, 2022 |
| Last update date |
Oct 19, 2022 |
| Contact name |
Rui Fu |
| Organization name |
University of Colorado Anschutz Medical Campus
|
| Department |
RNA Bioscience Initiative
|
| Lab |
Jay Hesselberth
|
| Street address |
13001 East 17th Place
|
| City |
Denver |
| State/province |
Colorado |
| ZIP/Postal code |
80202 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
| Samples (14)
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|
| Relations |
| BioProject |
PRJNA801698 |
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