|
| Status |
Public on Dec 31, 2009 |
| Title |
Genome-wide mapping of Myc binding site (K562) |
| Project |
ENCODE
|
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Proto-oncogene c-myc encodes a bHLH leucine-zipper containing transcription factor which has a DNA binding domain and a transactivation domain. Myc can dimerize with other factors like Max, Mad, Mnt and Miz and can influence transcription of genes. The c-myc oncogene contributes to the genesis of a wide variety of human tumors. A higher than normal level of c-myc gene expression has been observed in 50-80% of colon and breast cancers and a large proportion of human mortality from cancer is caused by abnormal expression of c-myc.
For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODEDataReleasePolicyFinal2008.pdf
|
| |
|
| Overall design |
Map binding sites of transcription factor Myc in the genome of K562 cells. The K562 input data has been deposited in GEO as GSM325934.
|
| Web link |
http://www.ncbi.nlm.nih.gov/projects/geo/info/ENCODE.html
|
| |
|
| Contributor(s) |
Raha D, Snyder M |
| Citation(s) |
20139302 |
| BioProject |
PRJNA63447 |
| |
| Submission date |
Dec 17, 2009 |
| Last update date |
May 15, 2019 |
| Contact name |
Flora Vaccarino |
| Organization name |
Yale University
|
| Department |
Child Study Center
|
| Lab |
Vaccarino
|
| Street address |
230 South Frontage Road
|
| City |
New Haven |
| State/province |
CT |
| ZIP/Postal code |
06520 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL9052 |
Illumina Genome Analyzer (Homo sapiens) |
|
| Samples (1) |
|
| This SubSeries is part of SuperSeries: |
| GSE19551 |
Close Association of RNA Polymerase II and Many Transcription Factors With Pol III Genes |
|
| Relations |
| SRA |
SRP001592 |
