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| Status |
Public on Jan 17, 2023 |
| Title |
Spatial multi-omics reveals vulnerabilities of radial glia-like cancer-initiating cells within distinct ecosystems of pediatric and adult malignant gliomas |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Other
|
| Summary |
We collected five DMG, five GBM (including two secondary GBM), and one peritumor samples from eleven patients requiring surgical resection. To establish an atlas for spatially-resolved gene expression, we performed short-read spatial transcriptomic sequencing on the tissue sections using the 10x Visium platform.
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| Overall design |
Here, we established a spatial atlas of H3K27M-DMG and GBM through short read spatial transcriptomics to reveal the niche-specific distribution and vulnerability of stem-like cells in H3K27M-DMG and GBM
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| |
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| Contributor(s) |
Huang Z, Ren Y, Zhou L, Xiao P, Song J, Chen L, Ju Y, Wang Y, Zhang Y |
| Citation(s) |
36823172 |
| |
| Submission date |
Jan 25, 2022 |
| Last update date |
Mar 14, 2023 |
| Contact name |
Yuan Wang |
| E-mail(s) |
wangyuan@scu.edu.cn
|
| Organization name |
Sichuan university
|
| Street address |
No.17 People's South Road
|
| City |
Chengdu |
| State/province |
Sichuan |
| ZIP/Postal code |
610041 |
| Country |
China |
| |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (11)
|
| GSM5833528 |
DMG1_short read spatial transcriptomics |
| GSM5833529 |
DMG2_short read spatial transcriptomics |
| GSM5833530 |
DMG3_short read spatial transcriptomics |
| GSM5833531 |
DMG4_short read spatial transcriptomics |
| GSM5833532 |
DMG5_short read spatial transcriptomics |
| GSM5833533 |
GBM1_short read spatial transcriptomics |
| GSM5833534 |
GBM2_short read spatial transcriptomics |
| GSM5833535 |
GBM3_short read spatial transcriptomics |
| GSM5833536 |
GBM4_short read spatial transcriptomics |
| GSM5833537 |
GBM5_1_short read spatial transcriptomics |
| GSM5833538 |
GBM5_2_short read spatial transcriptomics |
|
| Relations |
| BioProject |
PRJNA800338 |
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