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| Status |
Public on Jan 01, 2024 |
| Title |
Effect of neutrophil extracellular vesicles treatment on the K/BxN mouse model of arthritis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Arthritis was induced in C57BL/6 mice by injection of arthritogenic serum. This study aims to evaluate the transcriptomic profile of the K/BxN model of arthritis in knee joints, as well as he anti-inflammatory/tissue pro-repair effect of the intra-articular administration of neutrophil extracellular vesicles (EVs).
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| Overall design |
Four study groups were included: Disease (arthritic, n=4); Naive (healthy, n=4); Treated (arthritic, treated with EVs, n=8); Control (arthritic, treated with vehicle, n=8). Arthritis was induced with two injections of K/BxN arthritigenic serum on days 0 and 2. Treatments were applied on day 3. Mice were sacrificed on day 10.
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| Web link |
https://acrjournals.onlinelibrary.wiley.com/doi/10.1002/art.42958
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| Contributor(s) |
Thomas BL, Montero-Melendez T, Perretti M, Norling LV |
| Citation(s) |
39041647 |
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| Submission date |
Jan 21, 2022 |
| Last update date |
Aug 16, 2024 |
| Contact name |
Trinidad Montero |
| E-mail(s) |
t.monteromelendez@qmul.ac.uk
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| Organization name |
Whilliam Harvey Research Institute, Bart's and The London School of Medicine; Queen Mary University of London
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| Department |
Biochemical Pharmacology
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| Street address |
Charterhouse Square
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| City |
London |
| ZIP/Postal code |
EC1M 6BQ |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA799317 |
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