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Series GSE193945 Query DataSets for GSE193945
Status Public on Jul 15, 2022
Title The integrated stress response protects microtubule dynamics to recover from proteotoxic stress
Organism Mus musculus
Experiment type Other
Expression profiling by high throughput sequencing
Summary By performing ribosome profiling on squamous cell carcinoma stem cells (either control or S51A mutant) we found that the ISR translationally regulates a network of centrosomal proteins to help cellular recovery upon proteotoxic stress.
 
Overall design Ribosome profiling and total RNA sequencing were performed on control and S51A cells either vehicle-treated or treated with the proteosome inhibitor bortezomib for 4.5h
 
Contributor(s) Hurwitz B, Guzzi N, Barrows D, Carroll T, Fuchs E
Citation(s) 35758650
Submission date Jan 18, 2022
Last update date Jul 15, 2022
Contact name Douglas Barrows
E-mail(s) dbarrows@rockefeller.edu
Phone 7749940981
Organization name Rockefeller University
Street address 1230 York Ave
City New York
State/province NY
ZIP/Postal code 10065
Country USA
 
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (31)
GSM5823979 Sample_1_Ribo-Seq Ctrl_veh_1
GSM5823980 Sample_2_Ribo-Seq Ctrl_veh_2
GSM5823981 Sample_3_Ribo-Seq Ctrl_veh_3
Relations
BioProject PRJNA798445

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE193945_raw_counts_ribosome_profiling.csv.gz 301.1 Kb (ftp)(http) CSV
GSE193945_raw_counts_totalRNA_reseqMerge.csv.gz 491.6 Kb (ftp)(http) CSV
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Raw data are available in SRA
Processed data are available on Series record
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