|
| Status |
Public on Jul 26, 2022 |
| Title |
Longitudinal multi-omics analysis identifies early blood-based predictors of anti-TNF therapy response in inflammatory bowel disease [RNA-Seq] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We investigated the dynamics of gene expression in blood samples of IBD patients treated with infliximab and vedolizumab and analyzed the predictive potential regarding therapy outcome.
|
| |
|
| Overall design |
We performed a longitudinal, blood-based multi-omics study in two prospective IBD patient cohorts receiving first time infliximab therapy (discovery: 14 patients, replication: 23 patients) and one prospective IBD patient cohort receiving first time vedolizumab therapy (17 patients). Samples were collected at up to 7 timepoints (from baseline to 14 weeks after therapy induction).
|
| |
|
| Contributor(s) |
Mishra N, Aden K, Baran N, Rosentiel P |
| Citation(s) |
36153599, 38022524, 39444028 |
| |
| Submission date |
Dec 20, 2021 |
| Last update date |
Dec 13, 2024 |
| Contact name |
Neha Mishra |
| E-mail(s) |
n.mishra@ikmb.uni-kiel.de
|
| Organization name |
Institute of Clinical Molecular Biology
|
| Lab |
Cell biology Lab
|
| Street address |
Rosalind-Franklin-Str. 12
|
| City |
Kiel |
| ZIP/Postal code |
24105 |
| Country |
Germany |
| |
|
| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
|
| Samples (201)
|
|
| This SubSeries is part of SuperSeries: |
| GSE191331 |
Longitudinal multi-omics analysis identifies early blood-based predictors of anti-TNF therapy response in inflammatory bowel disease |
|
| Relations |
| BioProject |
PRJNA790985 |
Less...
More...