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| Status |
Public on Feb 08, 2022 |
| Title |
ChIP-seq data of CDYL in mouse dorsal root ganglia |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We report that the epigenetic factor CDYL is crucial for pain processing. CDYL downstreams in mouse dorsal root ganglia (DRG) are mostly associated with neurological functions, including chemical synaptic transmission, regulation of membrane potential and ion transport. CDYL facilitates H3K27me3 deposition at the Kcnb1 intron region thus silencing Kv2.1 transcription. Loss function of CDYL enhances total Kv and Kv2.1 current density in DRG and knockdown of Kv2.1 reverses the pain-related phenotypes of Cdyl deficiency mice.
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| |
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| Overall design |
Detection of CDYL downstreams in mouse primary sensory neurons
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| |
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| Contributor(s) |
Sun Z, Wang Y |
| Citation(s) |
35119221 |
| |
| Submission date |
Dec 13, 2021 |
| Last update date |
Feb 09, 2022 |
| Contact name |
Zhao-wei' Sun |
| E-mail(s) |
sunzhw@bjmu.edu.cn
|
| Organization name |
Peking University Health Science Center
|
| Street address |
38 Xue Yuan Road
|
| City |
Beijing |
| ZIP/Postal code |
100191 |
| Country |
China |
| |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
|
| Samples (6)
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|
| Relations |
| BioProject |
PRJNA789177 |
| SRA |
SRP351323 |
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