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Series GSE190056 Query DataSets for GSE190056
Status Public on Mar 24, 2022
Title Chicory: cutting the effects and the effectors for a functional food
Organism Mus musculus
Experiment type Expression profiling by array
Summary Whole chicory flour (Chic) and three compounds of chicory roots: fructose (Fru), chlorogenic acids (CGA) and sesquiterpene lactones (STL) were separately analyzed for their health effects in mice. A whole transcriptomic analysis was conducted using Agilent DNA microarrays to investigate their nutrigenomic effects.
 
Overall design Mice were fed with an aqueous decoction of the roots flour, with fructose, chlorogenic acids and sesquiterpene lactones solutions. The mice gavages consisted in a daily force-feeding of 500 µl of stemming solution decoctions of Chic, Fru, CGA or STL water solution besides the standard chow. As experiments were conducted for two different periods of time, two control sets were used: first control group (Ctr1) in parallel with chicory and fructose and a second control group (Ctr2) in parallel with CGA and STL. Three mice for each condition were sacrificed, 2 mice for Ctr1 and 2 mice for Ctr2. The central core of the liver left lobe was cut into cubes, a short segment (1 cm) of colon was also cut and enterocytes were harvested from upper ileal segments by mucosa scraping method. All these tissues were immediately frozen on liquid azote and stored as individual samples at -80°C for transcriptomics.
 
Contributor(s) Lucau-Danila A, Pouille C
Citation(s) 35267932
Submission date Dec 02, 2021
Last update date Mar 25, 2022
Contact name Anca Lucau-Danila
Organization name University of Lille
Department Biology
Lab Charles Viollette Institute
Street address Cité Scientifique SN2 303
City Villeneuve d'Ascq
ZIP/Postal code 59655
Country France
 
Platforms (1)
GPL10333 Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Feature Number version)
Samples (48)
GSM5712672 Liver 1 Control corresponding to chicory and fructose intake
GSM5712673 Liver 2 Control corresponding to chicory and fructose intake
GSM5712674 Liver 1 Control corresponding to CGA and STL intake
Relations
BioProject PRJNA785638

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE190056_Matrix_Caecum.xlsx 1.1 Mb (ftp)(http) XLSX
GSE190056_Matrix_Ileum.xlsx 1.1 Mb (ftp)(http) XLSX
GSE190056_Matrix_Liver.xlsx 948.8 Kb (ftp)(http) XLSX
GSE190056_RAW.tar 181.9 Mb (http)(custom) TAR (of GPR)
Processed data included within Sample table
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