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Series GSE189691 Query DataSets for GSE189691
Status Public on Dec 05, 2021
Title RNA sequencing of hippocampus of Prnp+/+ and PrnpZH3/ZH3 animals
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Purpose: Gain insight into the gene expression patterns altered in the PrnpZH3/ZH3 mice, that correleate with their neurobehavioural impaiments. Results: Around 700 genes showed alterations in their expression profile (323 upregulated and 390 downregulated in PrnpZH3/ZH3 compared to Prnp+/+).
Overall design Methods: Hippocampal mRNA profiles of 17-20-week-old wild-type (WT) or PRNP ZH3 knock out mice (PRNP(ZH3/ZH3)) mice were generated by deep sequencing, 8 replicates per group.
Contributor(s) Matamoros-Angles A, Hervera A, Soriano J, Marti E, Carulla P, Llorens F, Nuvolone M, Aguzzi A, Ferrer I, Gruart A, Delgado-Garcia JM, Del Rio JA
Citation(s) 35027047
Submission date Nov 28, 2021
Last update date Jan 31, 2022
Contact name Arnau Hervera
Organization name IBEC
Street address Baldiri Reixac 15-21
City Barcelona
ZIP/Postal code 08028
Country Spain
Platforms (1)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (16)
GSM5706038 Hippocampus WT rep1
GSM5706039 Hippocampus WT rep2
GSM5706040 Hippocampus WT rep3
BioProject PRJNA784185
SRA SRP348224

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE189691_normalized_log2_counts_ZH3.xlsx 5.9 Mb (ftp)(http) XLSX
GSE189691_raw_counts.txt.gz 900.1 Kb (ftp)(http) TXT
GSE189691_sample_summary_ZH3.xlsx 10.1 Kb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record

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