|
| Status |
Public on Jan 13, 2024 |
| Title |
Inherited blood cancer predisposition through altered transcription elongation [Pro-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Other
|
| Summary |
We identified CTR9 mutants as rare heritible contributing factors to several blood cancers. We later identified partial loss of CTR9 is capable of driving key hematopoietic maintenance and self-renewal gene expression through altered transcription elongation.
|
| |
|
| Overall design |
Examination of transcription elongation by Pro-seq on CD34+ HSPCs edited by AAVS1 and CTR9 sgRNAs
|
| |
|
| Contributor(s) |
Zhao J, Sankaran VG, Goldman S |
| Citation(s) |
38218188 |
| |
| Submission date |
Oct 26, 2021 |
| Last update date |
Jan 16, 2024 |
| Contact name |
Jiawei Zhao |
| E-mail(s) |
jiawei@broadinstitute.org
|
| Organization name |
Boston Children's Hospital
|
| Street address |
1 Blackfan Circle
|
| City |
Boston |
| State/province |
Massachusetts |
| ZIP/Postal code |
02115 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
| Samples (6)
|
|
| This SubSeries is part of SuperSeries: |
| GSE186591 |
Inherited blood cancer predisposition through altered transcription elongation |
|
| Relations |
| BioProject |
PRJNA774658 |
| SRA |
SRP343178 |
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