|
| Status |
Public on Jan 01, 2010 |
| Title |
Glucose Shortens the Lifespan of Caenorhabditis elegans by Down-Regulating Aquaporin Gene Expression |
| Organism |
Caenorhabditis elegans |
| Experiment type |
Expression profiling by array
|
| Summary |
Many studies have addressed the effect of dietary glycemic index on obesity and diabetes, but little is known about its effect on lifespan itself. We found that adding a small amount of glucose to the medium (0.1-2%) shortened the lifespan of C. elegans. Glucose shortened lifespan by inhibiting the activities of lifespan-extending transcription factors that are also inhibited by insulin signaling: the FOXO family member DAF-16 and the heat shock factor HSF-1. This effect involved the down-regulation of an aquaporin glycerol channel, aqp-1. We show that changes in glycerol metabolism are likely to underlie the lifespan-shortening effect of glucose, and that aqp-1 may act cell non-autonomously as a feedback regulator in the insulin/IGF-1 signaling pathway. Insulin down-regulates similar glycerol channels in mammals, suggesting that this glucose-responsive pathway might be conserved evolutionarily. Together these findings raise the possibility that a low-sugar diet might have beneficial effects on lifespan in higher organisms.
This SuperSeries is composed of the SubSeries listed below.
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| |
|
| Overall design |
Refer to individual Series.
|
| |
|
| Citation(s) |
19883616 |
| |
| Submission date |
Oct 14, 2009 |
| Last update date |
Dec 28, 2012 |
| Contact name |
SEUNG-JAE LEE |
| E-mail(s) |
SEUNGJAELEE1@GMAIL.COM
|
| Phone |
82-54-279-2351
|
| Organization name |
POHANG UNIVERSITY OF SCIENCE AND TECHNOLOGY
|
| Department |
LIFE SCEICNE
|
| Lab |
MOLECULAR GENETICS OF AGING
|
| Street address |
SAN 31 HYOJA-DONG, NAM-GU
|
| City |
POHANG |
| State/province |
GYEONGBUK |
| ZIP/Postal code |
790-784 |
| Country |
South Korea |
| |
|
| Platforms (1) |
| GPL9450 |
UCSF C. elegans 20K oligo array version 1 |
|
| Samples (14)
|
| GSM461962 |
daf-2 mutants treated with daf-16 RNAi vs. daf-2 mutants treated with empty vector RNAi replicate 1 |
| GSM461963 |
daf-2 mutants treated with daf-16 RNAi vs. daf-2 mutants treated with empty vector RNAi replicate 2 |
| GSM461964 |
daf-2 mutants treated with daf-16 RNAi vs. daf-2 mutants treated with empty vector RNAi replicate 3 |
| GSM461965 |
daf-2 mutants treated with daf-16 RNAi vs. daf-2 mutants treated with empty vector RNAi replicate 4 |
| GSM461966 |
daf-2 mutants treated with daf-16 RNAi vs. daf-2 mutants treated with empty vector RNAi replicate 5 |
| GSM461967 |
daf-2 mutants treated with daf-16 RNAi vs. daf-2 mutants treated with empty vector RNAi replicate 6 |
| GSM461968 |
daf-2 mutants treated with daf-16 RNAi vs. daf-2 mutants treated with empty vector RNAi replicate 7 |
| GSM461969 |
daf-2 mutants treated with daf-16 RNAi vs. daf-2 mutants treated with empty vector RNAi replicate 8 |
| GSM461970 |
Control animals vs. glucose-fed animals replicate 1 |
| GSM461971 |
Control animals vs. glucose-fed animals replicate 2 |
| GSM461972 |
Control animals vs. glucose-fed animals replicate 3 |
| GSM461973 |
Control animals vs. glucose-fed animals replicate 4 |
| GSM461974 |
Control animals vs. glucose-fed animals replicate 5 |
| GSM461975 |
Control animals vs. glucose-fed animals replicate 6 |
|
| This SuperSeries is composed of the following SubSeries: |
| GSE18561 |
Adult C. elegans: Control daf-2 mutants treated with daf-16 RNAi vs. daf-2 mutants treated with empty vector RNAi |
| GSE18562 |
Adult C. elegans: Control OP50 culture vs. OP50 + 2% glucose culture |
|
| Relations |
| BioProject |
PRJNA121381 |
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