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Series GSE18551 Query DataSets for GSE18551
Status Public on Jan 31, 2010
Title Striatum of Huntington's disease model mice [Affymetrix data]
Organism Mus musculus
Experiment type Expression profiling by array
Summary Evaluation of transcriptional changes in the striatum may be an effective approach to understanding the natural history of changes in expression contributing to the pathogenesis of Huntington disease (HD). We have performed genome-wide expression profiling of the YAC128 transgenic mouse model of HD at 12 and 24 months of age using two platforms in parallel; Affymetrix and Illumina. We performed gene expression profiling on the same striatal mRNA across both platforms.
Overall design Transgenic mice expressing human HD huntingtin with 120 CAG repeats (YAC128) and wildtype littermates were used for the described experiments. The mice were group housed in polystyrene cages under a normal light-dark cycle (6 am to 8 pm) in a clean facility and with free access to water and standard rodent chow. All experiments were performed in accordance with the University of British Columbia animal care committee. Striatal tissue was collected from 12 and 24 month old YAC128 mice and wildtype littermates.
Contributor(s) Pavlidis P, Becanovic K
Citation(s) 20089533
Submission date Oct 14, 2009
Last update date Feb 11, 2019
Contact name Paul Pavlidis
Organization name University of British Columbia
Department Centre for High-Throughput Biology / Psychiatry
Street address 177 Michael Smith Laboratories 2185 East Mall
City Vancouver
State/province British Columbia
ZIP/Postal code V6T 1Z4
Country Canada
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (18)
GSM461842 YAC128 mouse, 12 months of age (S1bis)
GSM461843 YAC128 mouse, 12 months of age (S2)
GSM461844 YAC128 mouse, 12 months of age (S3bis)
This SubSeries is part of SuperSeries:
GSE19677 Striatum of Huntington's disease model mice
BioProject PRJNA123785

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE18551_RAW.tar 67.3 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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