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| Status |
Public on Nov 23, 2022 |
| Title |
The dynamic rRNA ribomethylome drives stemness in acute myeloid leukemia [ribomethseq_FBL_KD] |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by high throughput sequencing
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| Summary |
We investigated the effect of FBL and SNRD127 on rRNA 2'-O-Me in human leukemai cell Kasumi-1.
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| Overall design |
FBL and SNORD127 were knocked down or knocked out from leukemia cell line Kasumi-1. Then we re-expressed wildtype, mutant FBL, SNORD127 or the empty control in the knockdown/knockout cells.
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| Contributor(s) |
Rohde C, Zhou F, Müller-Tidow C |
| Citation(s) |
36259929 |
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| Submission date |
Sep 24, 2021 |
| Last update date |
Nov 24, 2022 |
| Contact name |
Christian Rohde |
| E-mail(s) |
christian.rohde@uni-heidelberg.de
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| Organization name |
Heidelberg University
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| Lab |
Molecular Hematology and Oncology
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| Street address |
Im Neuenheimer Feld 410
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| City |
Heidelberg |
| ZIP/Postal code |
69120 |
| Country |
Germany |
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| Platforms (2) |
| GPL15456 |
Illumina HiScanSQ (Homo sapiens) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (19)
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| GSM5596389 |
Kasumi-1 cells, FBL knockdown replicate 1 |
| GSM5596390 |
Kasumi-1 cells, FBL knockdown replicate 2 |
| GSM5596391 |
Kasumi-1 cells, FBL knockdown plus FBLTri mutant replicate 1 |
| GSM5596392 |
Kasumi-1 cells, FBL knockdown plus FBLTri mutant replicate 2 |
| GSM5596393 |
Kasumi-1 cells, FBL knockdown plus empty replicate 1 |
| GSM5596394 |
Kasumi-1 cells, FBL knockdown plus empty replicate 2 |
| GSM5596395 |
Kasumi-1 cells, FBL knockdown plus FBLQuamutant replicate 1 |
| GSM5596396 |
Kasumi-1 cells, FBL knockdown plus FBLQua mutant replicate 2 |
| GSM5596397 |
Kasumi-1 cells, FBL knockdown plus wildtype FBL replicate 1 |
| GSM5596398 |
Kasumi-1 cells, FBL knockdown plus wildtype FBL replicate 2 |
| GSM5596399 |
Kasumi-1 cells, Control knockdown replicate 1 |
| GSM5596400 |
Kasumi-1 cells, Control knockdown replicate 2 |
| GSM5596401 |
Kasumi-1 cells, Control knockdown plus empty replicate 1 |
| GSM5596402 |
Kasumi-1 cells, Control knockdown plus empty replicate 2 |
| GSM5596403 |
Kasumi-1 cells, SNORD127 knockout clone C1 |
| GSM5596404 |
Kasumi-1 cells, SNORD127 knockout clone C1 plus empty |
| GSM5596405 |
Kasumi-1 cells, SNORD127 knockout clone C1 plus SNORD127 |
| GSM5596406 |
Kasumi-1 cells, SNORD127 control knockout clone |
| GSM5596407 |
Kasumi-1 cells, SNORD127 knockout clone C34 |
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| This SubSeries is part of SuperSeries: |
| GSE184728 |
The dynamic rRNA ribomethylome drives stemness in acute myeloid leukemia |
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| Relations |
| BioProject |
PRJNA765956 |
| SRA |
SRP338568 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE184724_RiboMethSeq_read_count.txt.gz |
233.8 Kb |
(ftp)(http) |
TXT |
| GSE184724_RiboMethSeq_scoreC.txt.gz |
19.1 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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