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| Status |
Public on Apr 24, 2022 |
| Title |
BAF complex cooperates with c-Myc to orchestrate early fate decisions of CD8 T cells (Microarray) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
We found cBAF and c-Myc co-assort asymmetrically to the two daughter nuclei, such that daughter cells with low c-Myc and cBAF display a cell fate trajectory towards memory T cell differentiation. Moreover, cBAF complex and c-Myc physically interact with each other, and act in establishing the chromatin landscape in activated CD8 T cells.
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| Overall design |
We used microarrary to compare transcriptional profile of sgNTC ('Spike_Smarcd2')- or sgSmarcd2-transduced P14 cells from the dual-color transfer system at day 7.5 post-infection from spleen; we used microarrary to compare transcriptional profile of sgNTC ('Spike_Arid1a')- or sgArid1a-transduced P14 cells from the dual-color transfer system at day 7.5 post-infection from spleen
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| Contributor(s) |
Huang H, Guo A, Chen MJ, Chi H, Green DR |
| Citation(s) |
35732731 |
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| Submission date |
Sep 22, 2021 |
| Last update date |
Jul 08, 2022 |
| Contact name |
Douglas R Green |
| E-mail(s) |
douglas.green@stjude.org
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| Organization name |
St Jude Children's Research Hospital
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| Department |
Immunology
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| Lab |
Green lab
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| Street address |
262 Danny Thomas Pl
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| City |
Memphis |
| State/province |
United States |
| ZIP/Postal code |
38105 |
| Country |
USA |
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| Platforms (1) |
| GPL23038 |
[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay) |
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| Samples (16)
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| This SubSeries is part of SuperSeries: |
| GSE183619 |
BAF complex cooperates with c-Myc to orchestrate early fate decisions of CD8 T cells |
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| Relations |
| BioProject |
PRJNA765308 |
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