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| Status |
Public on Feb 27, 2022 |
| Title |
Transcriptome analysis of liver tumors derived from human induced liver cancer-forming cells (iLCCs) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We found that a set of six transcription factors, FOXA3, HNF1A, HNF1B, LIN28B, L-MYC, and KLF5, can induce direct conversion of human umbilical vein endothelial cells (HUVECs) into liver cancer-forming cells (LCCs). These induced LCCs (iLCCs) efficiently give rise to tumors that closely resemble human combined hepatocellular cholangiocarcinoma after transplantation to immunodeficient mice. We conducted RNA-seq analyses to investigate the characteristincs of the tumors derived from iLCCs.
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| Overall design |
RNA-Seq analyses for the tumors derived from iLCCs.
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| Contributor(s) |
Suzuki A, Ohkawa Y, Horisawa K, Goya T |
| Citation(s) |
35220676 |
| |
| Submission date |
Sep 21, 2021 |
| Last update date |
May 29, 2022 |
| Contact name |
Atsushi Suzuki |
| Organization name |
Kyushu University
|
| Department |
Medical Institute of Bioregulation
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| Lab |
Division of Organogenesis and Regeneration
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| Street address |
3-1-1 Maidashi, Higashi-ku
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| City |
Fukuoka |
| State/province |
Fukuoka |
| ZIP/Postal code |
812-8582 |
| Country |
Japan |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA765004 |
| SRA |
SRP338086 |
