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| Status |
Public on Apr 24, 2022 |
| Title |
BAF complex cooperates with c-Myc to orchestrate early fate decisions of CD8 T cells (RNA-seq) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We found cBAF and c-Myc co-assort asymmetrically to the two daughter nuclei, such that daughter cells with low c-Myc and cBAF display a cell fate trajectory towards memory T cell differentiation. Moreover, cBAF complex and c-Myc physically interact with each other, and act in establishing the chromatin landscape in activated CD8 T cells.
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| Overall design |
RNA-seq analysis of 20 samples: Activated CD8 T cells (n=5); Activated c-Myc KO CD8 T cells (n=5); First-division WT CD8 T cells (n=5); First division Arid1a KO CD8 T cells (n=5)
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| |
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| Contributor(s) |
Guo A, Huang H, Chen MJ, Chi H, Green DR |
| Citation(s) |
35732731 |
| |
| Submission date |
Sep 07, 2021 |
| Last update date |
Jul 08, 2022 |
| Contact name |
Douglas R Green |
| E-mail(s) |
douglas.green@stjude.org
|
| Organization name |
St Jude Children's Research Hospital
|
| Department |
Immunology
|
| Lab |
Green lab
|
| Street address |
262 Danny Thomas Pl
|
| City |
Memphis |
| State/province |
United States |
| ZIP/Postal code |
38105 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (20)
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| This SubSeries is part of SuperSeries: |
| GSE183619 |
BAF complex cooperates with c-Myc to orchestrate early fate decisions of CD8 T cells |
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| Relations |
| BioProject |
PRJNA761410 |
| SRA |
SRP336042 |
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