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| Status |
Public on Jan 07, 2022 |
| Title |
Genomic profiles of oxidative stress-induced renal cell carcinomas developed in A/J mice |
| Organism |
Mus musculus |
| Experiment type |
Genome variation profiling by genome tiling array
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| Summary |
Intraperitoneal administration of ferric nitrilotriacetate initiates Fenton reaction in the renal proximal tubules in rodents. Its repeated administration ultimately leads to the development of renal cell carcinoma (RCC). We performed high-resolution microarray comparative genomic hybridization to identify characteristics in the genomic profiles of oxidative stress-induced RCCs in the mice of A/J strain.
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| Overall design |
The carcinogenesis protocol was started with 58 male A/J mice. Eighteen of the mice developed a renal cell carcinoma in total. Genomes of 4 samples from the RCCs were profiled on Agilent 180K mouse genome CGH microarrays.
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| Contributor(s) |
Zhen C, Shinya A, Shinya T |
| Citation(s) |
34699654 |
| |
| Submission date |
Sep 01, 2021 |
| Last update date |
Jan 10, 2022 |
| Contact name |
Shinya Toyokuni |
| E-mail(s) |
akatsuka@med.nagoya-u.ac.jp
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| Organization name |
Nagoya University
|
| Department |
Pathology
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| Street address |
65 Tsuruma-Cho, Showa-Ku
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| City |
Nagoya |
| State/province |
Aichi |
| ZIP/Postal code |
466-8550 |
| Country |
Japan |
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| Platforms (1) |
| GPL10449 |
Agilent-027411 SurePrint G3 Mouse CGH Microarray 4x180K (Feature Number version) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA759559 |
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