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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Jan 07, 2022 |
| Title |
AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation [Hs] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We identified enrichment of a disease-enhancing, proinflammatory subpopulation of microglia in human AD patient brains with the R47H-TREM2 mutation, and uncovered that enhanced Akt signaling in microglia underlies the proinflammatory cytokine state and synaptic toxicity in our R47H-TREM2 tauopathy mouse model.
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| Overall design |
Droplet-based single nuclear RNA sequencing of frontal cortical tissues from AD patient with and without the TREM2-R47H mutation and their age, pathology, and sex-matched, controls
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| Contributor(s) |
Sayed FA, Kodama L, Fan L, Carling GK, Udeochu JC, Le D, Li Q, Zhou L, Wong MY, Horowitz R, Ye P, Mathys H, Wang M, Niu X, Mazutis L, Jiang X, Wang X, Gao F, Brendel M, Telpoukhovskaia M, Tracy TE, Frost G, Zhou Y, Li Y, Cheng Z, Yu G, Hardy J, Coppola G, Gong S, Wang F, DeTure MA, Zhang B, Xie L, Trajnowski JQ, Lee VM, Sinha S, Dickson DW, Luo W, Gan L |
| Citation(s) |
34851693 |
| BioProject |
PRJNA754520 |
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| Submission date |
Aug 30, 2021 |
| Last update date |
Jan 08, 2022 |
| Contact name |
Li Gan |
| E-mail(s) |
lig2033@med.cornell.edu
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| Phone |
6087704342
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| Organization name |
Weill Cornell Medicine
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| Department |
Helen and Robert Appel Alzheimer’s Disease Research Institute
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| Lab |
Gan lab
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| Street address |
413 East 69th Street, 9th Floor BB904
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| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10021 |
| Country |
USA |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (55)
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| Supplementary file |
Size |
Download |
File type/resource |
| GSE183068_RAW.tar |
4.5 Gb |
(http)(custom) |
TAR (of MTX, TSV) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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