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Series GSE18195 Query DataSets for GSE18195
Status Public on Sep 22, 2009
Title Effects of bevacizumab (avastin) in mouse model of endometrial cancer
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Microarrays were used to determine the efficacy of bevacizumab (a monoclonal antibody against the vascular endothelial growth factor and its receptors.) on endometrial cancer cells.
Endometrial cancer is the most frequent gynecologic cancer in women. Long term outcomes for patients with advanced stage or recurrent disease are poor. Targeted molecular therapy against the vascular endothelial growth factor (VEGF) and its receptors constitute a new therapeutic option for these patients. The goal of our work was to assess the potential effectiveness of inhibition of VEGF/VEGFR signaling in a xenograft model of endometrial cancer using bevacizumab (Avastin, a humanized antibody against VEGFA). We also aimed to identify molecular markers of sensitivity or resistance to this agent. We show that bevacizumab retards tumor growth in athymic mice by inhibiting molecular components of signaling pathways that sustain cell survival and proliferation. We also demonstrate that resistance to bevacizumab may involve up-regulation of antiapoptotic genes and certain proto-oncogenes.
Overall design Human xenografts produced from endometrial cell line, grown in athymic mice, were treated in vivo with bevacizumab.
Contributor(s) Pickett G, Davies S, Leslie KK, Dai D
Citation(s) 21240464
Submission date Sep 21, 2009
Last update date Jan 08, 2019
Contact name Gavin Pickett
Organization name UNM
Department Genomics
Street address 2325 Camino de Salud NE
City Albuquerque
State/province NM
ZIP/Postal code 87131
Country USA
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (4)
GSM454881 071019_Undosed control, biological rep1
GSM454882 071019_Undosed control, biological rep2
GSM454883 Avastin dosed, biological rep1
BioProject PRJNA119509

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Supplementary file Size Download File type/resource
GSE18195_RAW.tar 20.8 Mb (http)(custom) TAR (of CEL, CHP)
Raw data provided as supplementary file
Processed data included within Sample table
Processed data provided as supplementary file

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