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Status |
Public on Oct 05, 2021 |
Title |
MALT1-dependent cleavage of HOIL1 modulates canonical NF-kB signaling and inflammatory responsiveness |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
From patient-derived HOIL1-deficient skin fibroblasts transduced with WT and p.Arg165Lys (R/K) HOIL1, we performed differential expression analysis, gene set enrichment, and pathway analyses by RNA-Seq to demonstrate exaggerated activation of inflammatory pathways.
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Overall design |
Transcriptome profiling of untransduced and WT or p.Arg165Lys (R/K) HOIL1-transduced HOIL1-deficient patient skin fibroblasts in technical triplicate, with or without stimulation (4hrs 10ng/mL IL-1b)
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Contributor(s) |
Lu HY, Fung S, Sharma M, Sharma AA, Turvey SE |
Citation(s) |
34721419 |
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Submission date |
Aug 04, 2021 |
Last update date |
Nov 19, 2021 |
Contact name |
Stuart E Turvey |
E-mail(s) |
sturvey@cw.bc.ca
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Phone |
6048753131
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Organization name |
The University of British Columbia
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Department |
Pediatrics
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Street address |
A5-122 950 W 28th Avenue
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City |
Vancouver |
State/province |
British Columbia |
ZIP/Postal code |
V5Z 4H4 |
Country |
Canada |
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Platforms (1) |
GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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Samples (18)
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Relations |
BioProject |
PRJNA752167 |
SRA |
SRP331171 |