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| Status |
Public on Oct 05, 2021 |
| Title |
MALT1-dependent cleavage of HOIL1 modulates canonical NF-kB signaling and inflammatory responsiveness |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
From patient-derived HOIL1-deficient skin fibroblasts transduced with WT and p.Arg165Lys (R/K) HOIL1, we performed differential expression analysis, gene set enrichment, and pathway analyses by RNA-Seq to demonstrate exaggerated activation of inflammatory pathways.
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| Overall design |
Transcriptome profiling of untransduced and WT or p.Arg165Lys (R/K) HOIL1-transduced HOIL1-deficient patient skin fibroblasts in technical triplicate, with or without stimulation (4hrs 10ng/mL IL-1b)
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| |
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| Contributor(s) |
Lu HY, Fung S, Sharma M, Sharma AA, Turvey SE |
| Citation(s) |
34721419 |
| |
| Submission date |
Aug 04, 2021 |
| Last update date |
Nov 19, 2021 |
| Contact name |
Stuart E Turvey |
| E-mail(s) |
sturvey@cw.bc.ca
|
| Phone |
6048753131
|
| Organization name |
The University of British Columbia
|
| Department |
Pediatrics
|
| Street address |
A5-122 950 W 28th Avenue
|
| City |
Vancouver |
| State/province |
British Columbia |
| ZIP/Postal code |
V5Z 4H4 |
| Country |
Canada |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA752167 |
| SRA |
SRP331171 |
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