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Series GSE181493 Query DataSets for GSE181493
Status Public on Oct 05, 2021
Title MALT1-dependent cleavage of HOIL1 modulates canonical NF-kB signaling and inflammatory responsiveness
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary From patient-derived HOIL1-deficient skin fibroblasts transduced with WT and p.Arg165Lys (R/K) HOIL1, we performed differential expression analysis, gene set enrichment, and pathway analyses by RNA-Seq to demonstrate exaggerated activation of inflammatory pathways.
 
Overall design Transcriptome profiling of untransduced and WT or p.Arg165Lys (R/K) HOIL1-transduced HOIL1-deficient patient skin fibroblasts in technical triplicate, with or without stimulation (4hrs 10ng/mL IL-1b)
 
Contributor(s) Lu HY, Fung S, Sharma M, Sharma AA, Turvey SE
Citation(s) 34721419
Submission date Aug 04, 2021
Last update date Nov 19, 2021
Contact name Stuart E Turvey
E-mail(s) sturvey@cw.bc.ca
Phone 6048753131
Organization name The University of British Columbia
Department Pediatrics
Street address A5-122 950 W 28th Avenue
City Vancouver
State/province British Columbia
ZIP/Postal code V5Z 4H4
Country Canada
 
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (18)
GSM5503509 Untransduced_unstim_A
GSM5503510 Untransduced_unstim_B
GSM5503511 Untransduced_unstim_C
Relations
BioProject PRJNA752167
SRA SRP331171

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE181493_Normalized_counts.csv.gz 1.1 Mb (ftp)(http) CSV
GSE181493_Raw_counts.csv.gz 553.0 Kb (ftp)(http) CSV
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Raw data are available in SRA
Processed data are available on Series record

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