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Series GSE181454 Query DataSets for GSE181454
Status Public on Aug 05, 2021
Title scRNA-seq of P20 mouse cochlea
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary ARHL has been thought to result from disordered hair cell function and their loss. ARHL has a significant genetic component. We sought to determine the expression in the cochlea of genes associated with single nucleotide polymorphisms linked to ARHL. We find widespread and varying expression of genes associated with these SNPs in subtypes of cells in the cochlea identified by single-cell RNA sequencing. Genes associated with SNPs with the highest significance were preferentially expressed highly in hair cells while genes associated with SNPs with a lower significance were expressed more universally.
Overall design Examination of expression patterns of genes expressed in day 20 mouse cochlea.
Contributor(s) Xue N, Song L, Wu H, Navaratnam D
Citation(s) 34536825
Submission date Aug 04, 2021
Last update date Nov 04, 2021
Contact name Na Xue
Organization name Shanghai Jiaotong University School of Medicine
Department Otolaryngology
Street address Zhizaoju Road 639
City Shanghai
ZIP/Postal code 200011
Country China
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (2)
GSM5502627 P20 mouse cochlea 1
GSM5502628 P20 mouse cochlea 2
BioProject PRJNA752099
SRA SRP331113

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE181454_RAW.tar 16.3 Mb (http)(custom) TAR (of MTX, TSV)
GSE181454_Supplementary_datasets_1.xlsx 306.4 Mb (ftp)(http) XLSX
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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