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Series GSE180980 Query DataSets for GSE180980
Status Public on May 18, 2022
Title Nanchangmycin exerts antifibrotic activity by inhibiting collagen production, migration, and proliferation of hepatic stellate cells
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We report the RNA sequencing results of human primary hepatic stellate cells (HSCs) treated with DMSO or 1 ┬ÁM nanchangmycin (NCMC) for 48 hours. We find that multiple HSC activity and liver fibrosis related gene signatures, including ECM-related gene signatures, are negatively enriched in nanchangmycin treated HSCs.
Overall design Examination of mRNA expression by RNA sequencing in DMSO or nanchangmycin treated hepatic stellate cells.
Contributor(s) Li W, Rahman R, Moran S, Mullen AC
Citation(s) 35617485
Submission date Jul 27, 2021
Last update date Jun 01, 2022
Contact name Alan C. Mullen
Organization name Massachusetts General Hospital
Department Department of Medicine
Street address 55 Fruit St.
City Boston
State/province MA
ZIP/Postal code 02135
Country USA
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (5)
GSM5481664 Hepatic stellate cells - DMSO treated - replicate 1
GSM5481665 Hepatic stellate cells - DMSO treated - replicate 2
GSM5481666 Hepatic stellate cells - NCMC treated - replicate 1
BioProject PRJNA750218
SRA SRP330115

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE180980_FilteredDifferentialExpression_min5reads_control_vs_NCMC.txt.gz 1.6 Mb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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