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Series GSE18024 Query DataSets for GSE18024
Status Public on Sep 12, 2009
Title FIA plasma induces arthritis in naïve mice
Platform organisms Homo sapiens; Mus musculus
Sample organism Mus musculus
Experiment type Protein profiling by protein array
Summary Plasma collected from mice with FIA were pooled, and 0.3 ml was injected intravenously into 6-week-old naïve SJL mice on days 0 and 2. Synovial antigen array profiling of plasma from the arthritic recipient mice demonstrated autoreactive B-cell responses against peptides representing native fibrinogen and citrullinated fibrinogen, and further epitope spreading resulting in additional targeting of fibronectin, collagen type V, cartilage gp39, and clusterin.
Overall design Custom-spotted protein slides were probed with plasma samples from individual mice. Four slides were probed with plasma derived from naïve mice and four slides were probed with plasma derived from mice injected with FIA plasma.
Contributor(s) Ho PP, Lee LY, Zhao X, Tomooka BH, Paniagua RT, Sharpe O, BenBarak MJ, Hueber W, Chandra PE, Steinman L, Robinson WH
Citation(s) 19949094
Submission date Sep 09, 2009
Last update date Mar 21, 2012
Contact name William Robinson
Phone 6508491207
Fax 6508491208
Organization name Stanford University
Street address 269 Campus Dr
City Stanford
State/province CA
ZIP/Postal code 94305
Country USA
Platforms (1)
GPL9165 Synovial protein array 0.5K v2.0
Samples (8)
GSM450723 Naive - 1
GSM450724 Naive - 2
GSM450725 Naive - 3
This SubSeries is part of SuperSeries:
GSE18073 Mice with fibrinogen-induced arthritis (FIA)
BioProject PRJNA123463

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE18024_RAW.tar 900.0 Kb (http)(custom) TAR (of GPR)
Processed data included within Sample table

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