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| Status |
Public on Oct 10, 2022 |
| Title |
ATAC-seq of antigen-specific CD8+ T cells from tumor draining LNs of melanoma bearing mice |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
CD8+ T cell-mediated immune response plays a pivotal role in controlling tumor growth.However, within the tumor microenvironment (TME), prolonged antigen exposure, as well as immunosuppressive factors, drive infiltrated tumor-specific CD8+ T cells into a hyporesponsive state known as “exhaustion”. Notably, our current understanding of tumor-specific CD8+ T cells mainly comes from experiments focusing on tumor infiltrated T cells, less is known about those in tumor draining LNs. Hence, we profiled the chromosome accessibilities of antigen-specific CD8+ T cells from tumor draining LNs of melanoma bearing mice in this project, aiming to draw a comprehensive immune-atlas of tumor-specific CD8+ T cells during tumorigenesis.
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| Overall design |
We performed ATAC-Seq on antigen specific CD8+ T cells (P14) originated from TdLNs (tumor draining lymph nodes) of melanoma tumor model at indicated time points post P14 cell transfer.
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| Contributor(s) |
Huang Q, Xu L, Wu X, Wang Z, Chen X, Dong W |
| Citation(s) |
36208623 |
| |
| Submission date |
Jul 14, 2021 |
| Last update date |
Oct 11, 2022 |
| Contact name |
lilin ye |
| E-mail(s) |
yelilinlcmv@tmmu.edu.cn
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| Organization name |
Third Military Medical University
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| Department |
Institute of Immunology
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| Street address |
Gaotanyan Street, Shapingba District
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| City |
Chongqing |
| ZIP/Postal code |
400038 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (9)
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| This SubSeries is part of SuperSeries: |
| GSE180095 |
Antigen-specific CD8+ T cells from tumor draining of melanoma bearing mice |
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| Relations |
| BioProject |
PRJNA746488 |
| SRA |
SRP328301 |
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