|
| Status |
Public on Jan 31, 2024 |
| Title |
Gene expression changes in REH following STAT3 pharmacological inhibition |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
STAT3 (Signal transducer and activator of transcription 3) expression is associated with with t(12;21) acute lymphoblastic leukaemia (ALL) and it is crucial for the survival of the t(12;21) ALL . Our study investigated the STAT3 regulated pathways and discovered a novel STAT3-TP53 axis in B-ALL. In order to determine the STAT3 regulated pathways in t(12;21) ALL cells, we performed RNAseq analysis on the Pre-B Acute Lymphoblastic Leukemia (ALL) cell line REH, treated with DMSO vehicle control in comparison to 50uM S3I-021, a specific STAT3 inhibitor
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| |
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| Overall design |
Total cellular RNA was purified from DMSO and 50uM S3I-201 treated REH samples from three independent experiments
|
| Web link |
https://haematologica.org/article/view/haematol.2023.283613
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| |
|
| Contributor(s) |
Gasparoli L, de Boer J, Williams O |
| Citation(s) |
37794795 |
| |
| Submission date |
Jul 02, 2021 |
| Last update date |
Jan 31, 2024 |
| Contact name |
Luca Gasparoli |
| E-mail(s) |
lucagasparoli@gmail.com
|
| Organization name |
UCL Great Ormond Institute of Child Health
|
| Department |
Developmental Biology and Cancer
|
| Street address |
30 Guilford Street, Location 1B
|
| City |
London |
| ZIP/Postal code |
WC1N 1EH |
| Country |
United Kingdom |
| |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (6)
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|
| Relations |
| BioProject |
PRJNA743296 |
| SRA |
SRP326661 |
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