|
Status |
Public on Jan 31, 2024 |
Title |
Gene expression changes in REH following STAT3 inhibition by shRNA |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by high throughput sequencing
|
Summary |
STAT3 (Signal transducer and activator of transcription 3) expression is associated with with t(12;21) acute lymphoblastic leukaemia (ALL) and it is crucial for the survival of the t(12;21) ALL . Our study investigated the STAT3 regulated pathways and discovered a novel STAT3-TP53 axis in B-ALL. In order to determine the STAT3 regulated pathways in t(12;21) ALL cells, we performed RNAseq analysis on the Pre-B Acute Lymphoblastic Leukemia (ALL) cell line REH following shRNA-mediated STAT3 knockdown
|
|
|
Overall design |
Total cellular RNA was purified from control scramble or shSTAT3 transduced REH samples from three independent experiments
|
Web link |
https://haematologica.org/article/view/haematol.2023.283613
|
|
|
Contributor(s) |
Gasparoli L, de Boer J, Williams O |
Citation(s) |
37794795 |
|
Submission date |
Jul 02, 2021 |
Last update date |
Jan 31, 2024 |
Contact name |
Luca Gasparoli |
E-mail(s) |
lucagasparoli@gmail.com
|
Organization name |
UCL Great Ormond Institute of Child Health
|
Department |
Developmental Biology and Cancer
|
Street address |
30 Guilford Street, Location 1B
|
City |
London |
ZIP/Postal code |
WC1N 1EH |
Country |
United Kingdom |
|
|
Platforms (1) |
GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
Samples (6)
|
|
Relations |
BioProject |
PRJNA743292 |
SRA |
SRP326664 |