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Series GSE179332 Query DataSets for GSE179332
Status Public on Jan 31, 2024
Title Gene expression changes in REH following STAT3 inhibition by shRNA
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary STAT3 (Signal transducer and activator of transcription 3) expression is associated with with t(12;21) acute lymphoblastic leukaemia (ALL) and it is crucial for the survival of the t(12;21) ALL . Our study investigated the STAT3 regulated pathways and discovered a novel STAT3-TP53 axis in B-ALL. In order to determine the STAT3 regulated pathways in t(12;21) ALL cells, we performed RNAseq analysis on the Pre-B Acute Lymphoblastic Leukemia (ALL) cell line REH following shRNA-mediated STAT3 knockdown
 
Overall design Total cellular RNA was purified from control scramble or shSTAT3 transduced REH samples from three independent experiments
Web link https://haematologica.org/article/view/haematol.2023.283613
 
Contributor(s) Gasparoli L, de Boer J, Williams O
Citation(s) 37794795
Submission date Jul 02, 2021
Last update date Jan 31, 2024
Contact name Luca Gasparoli
E-mail(s) lucagasparoli@gmail.com
Organization name UCL Great Ormond Institute of Child Health
Department Developmental Biology and Cancer
Street address 30 Guilford Street, Location 1B
City London
ZIP/Postal code WC1N 1EH
Country United Kingdom
 
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (6)
GSM5415396 REH scramble control_1
GSM5415397 REH scramble control_2
GSM5415398 REH scramble control_3
Relations
BioProject PRJNA743292
SRA SRP326664

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE179332_SCR_vs_shSTAT3_REH_deseq.csv.gz 465.3 Kb (ftp)(http) CSV
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Raw data are available in SRA
Processed data are available on Series record

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