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| Status |
Public on Dec 15, 2021 |
| Title |
Inflammatory molecular endotypes of nasal polyps derived from Caucasian and Japanese populations |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Chronic rhinosinusitis with nasal polyps is a hallmaerk disease in the field of upper airway immunity and chronic inflammation. Diverse inflammatory patterns between nasal polyps have been described in patients that hail from disparate racial and geographic backgrounds. However, it remains unclear whether these immunologic differences in nasal polyps between racial groups are driven by unique molecular mechanisms. We interrogated the gene expression profiles of nasal polyp tissues from Western (United States) and East Asian (Japan) descent, compared to ethmoid sinus tissue controls.
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| Overall design |
Examination of the key cell types that express critical molecular genes that differentiate between nasal polyp endtypes from 2 nasal polyp samples using droplet-based single-cell RNAseq.
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| Contributor(s) |
Nakayama T, Lee I, Ziang S, Nayak JV |
| Citation(s) |
34863854 |
| |
| Submission date |
Jul 01, 2021 |
| Last update date |
Dec 15, 2021 |
| Contact name |
Tsuguhisa Nakayama |
| Organization name |
Stanford University
|
| Department |
Department of Otolaryngology-Head and Neck Surgery
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| Street address |
801 Welch Road
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| City |
Stanford |
| State/province |
CA |
| ZIP/Postal code |
94305 |
| Country |
USA |
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| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
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| Samples (2) |
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| This SubSeries is part of SuperSeries: |
| GSE179269 |
Inflammatory molecular endotypes of nasal polyps derived from Caucasian and Japanese populations |
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| Relations |
| BioProject |
PRJNA743036 |
| SRA |
SRP326495 |
