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Series GSE178967 Query DataSets for GSE178967
Status Public on Oct 01, 2021
Title Baseline signatures associated with clinical, virologic, and immunologic outcomes in patients with mild to moderate COVID-19
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary The vast majority of SARS-CoV-2 infections are uncomplicated and do not require hospitalization, but these infections contribute to ongoing transmission. There remains a critical need to identify host immune biomarkers predictive of virologic and clinical outcomes in planning future treatment studies of COVID-19. We recently completed a randomized clinical trial of Pegylated PegIinterferon Lambda for treatment of SARS-CoV-2 infected patients conducted in the Stanford COVID-19 CTRU. Leveraging longitudinal samples and data from this trial, we define early immunebaseline and infection-induced signatures that predict the duration of viral shedding, resolution of symptoms, and immunologic memory.
 
Overall design We recruited 108 subjects between age 18 to 75 who are PCR positive for SARS-CoV-2. The subjects were randomized to receive a single dose of Peginterferon Lambda or placebo at their first visit (day 0). In-person follow-up visits were conducted on Day 1, 3, 5, 7, 10, 14, 21, and 28, with the assessment of symptoms and vitals and collection of oropharyngeal swabs for SARS-CoV-2 testing. To profile the immune response in the COVID-19 patients, we conducted RNA-sequencing assays using blood samples collected at day 0 and day 5 after enrollment.
 
Contributor(s) Jagannathan P, Hu Z, van der Ploeg K, Martinez Mori DA
Citation(s) 35132407, 36239699
Submission date Jun 26, 2021
Last update date Oct 28, 2022
Contact name Zicheng Hu
E-mail(s) hzc363@gmail.com
Organization name University of California San Francisco
Street address 490 Illinois Street
City San Francisco
ZIP/Postal code 94158
Country USA
 
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (180)
GSM5402242 L_136_05: COVID19 patient 136 day 5
GSM5402243 L_173_00: COVID19 patient 173 day 0
GSM5402244 L_112_05: COVID19 patient 112 day 5
Relations
BioProject PRJNA741686
SRA SRP325729

Download family Format
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE178967_RNAseq_counts.csv.gz 67.1 Mb (ftp)(http) CSV
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Raw data are available in SRA
Processed data are available on Series record

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