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Series GSE175568 Query DataSets for GSE175568
Status Public on Aug 10, 2021
Title Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We provide RNA sequencing data for a Ccnd2/p53/Mb1Cre mouse model (Mb1Cre is active from pre-B cells onwards). This mouse model features Ccnd2 overexpression and p53 loss in B-cells, and develops tumors that resembles Mantle cell lymphoma (MCL). These Ccnd2/p53/Mb1Cre mice develop both non-MCL and MCL-like lymphomas and RNA samples from both groups were sequenced. Fresh lymphoma cells (5x10exp6) were frozen in 700 µl of QIAZOL and stored in -80°C. RNA was prepared using a miRNeasy mini kit (Qiagen).
 
Overall design mRNA profiles from non-MCL and MCL-like murine Ccnd2/p53/Mb1Cre lymphomas
 
Contributor(s) Van Vlierberghe P, Pieters T, Van Loocke W
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Submission date May 26, 2021
Last update date Aug 11, 2021
Contact name Wouter Van Loocke
E-mail(s) wouter.vanloocke@ugent.be
Organization name Ghent University
Department Biomolecular Medicine
Street address C. Heymanslaan 10
City Ghent
State/province East Flanders
ZIP/Postal code 9000
Country Belgium
 
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (22)
GSM5341836 primary non-MCL Ccnd2/p53/Mb1Cre lymphoma TP8
GSM5341837 primary non-MCL Ccnd2/p53/Mb1Cre lymphoma TP15
GSM5341838 primary non-MCL Ccnd2/p53/Mb1Cre lymphoma oTP14b
Relations
BioProject PRJNA732916
SRA SRP321448

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE175568_countMatrix_TP.txt.gz 741.2 Kb (ftp)(http) TXT
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Processed data are available on Series record
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