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Series GSE17482 Query DataSets for GSE17482
Status Public on Apr 30, 2010
Title Gene expression profiles regulated by Stat5a/b vs. Stat3 in human prostate cancer cells.
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Identification of the molecular changes that promote viability and metastatic behavior of prostate cancer cells is critical for the development of improved therapeutic interventions for prostate cancer. Stat5a/b and Stat3 are both constitutively active in locally-confined and advanced prostate cancer, and both transcription factors have been reported to be critical for the viability and growth of prostate cancer cells.
We used microarrays to compare gene expression profiles regulated by Stat5a/b vs. Stat3 in human prostate cancer cells.
 
Overall design DU145 and CWR22Rv1 human prostate cancer cells were transfected with Stat3 siRNA, Stat5a/b siRNA or scramble siRNA as control. After 48 h, the cells were harvested and total RNA was prepared for Affymetrix microarrays.
 
Contributor(s) Gu L, Dagvadorj A, Lutz J, Leiby B, Bonucelli G, Lisanti MP, Addya S, Fortina P, Dasgupta A, Hyslop TM, Rhimm J, Bubendorf L, Nevalainen MT
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Submission date Aug 03, 2009
Last update date Mar 25, 2019
Contact name Marja Nevalainen
E-mail(s) Marja.Nevalainen@jefferson.edu
Phone 215-503-9250
Fax 215-503-9245
Organization name Thomas Jefferson University
Department Cancer Biology
Lab Nevalainen
Street address 233 S. 10th St
City Philadelphia
State/province PA
ZIP/Postal code 19107
Country USA
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (18)
GSM435992 DU145_ctrl#1
GSM435993 DU145_ctrl#2
GSM435994 DU145_ctrl#3
Relations
BioProject PRJNA118767

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Supplementary file Size Download File type/resource
GSE17482_RAW.tar 81.9 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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