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| Status |
Public on Apr 30, 2010 |
| Title |
Gene expression profiles regulated by Stat5a/b vs. Stat3 in human prostate cancer cells. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Identification of the molecular changes that promote viability and metastatic behavior of prostate cancer cells is critical for the development of improved therapeutic interventions for prostate cancer. Stat5a/b and Stat3 are both constitutively active in locally-confined and advanced prostate cancer, and both transcription factors have been reported to be critical for the viability and growth of prostate cancer cells.
We used microarrays to compare gene expression profiles regulated by Stat5a/b vs. Stat3 in human prostate cancer cells.
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| Overall design |
DU145 and CWR22Rv1 human prostate cancer cells were transfected with Stat3 siRNA, Stat5a/b siRNA or scramble siRNA as control. After 48 h, the cells were harvested and total RNA was prepared for Affymetrix microarrays.
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| Contributor(s) |
Gu L, Dagvadorj A, Lutz J, Leiby B, Bonucelli G, Lisanti MP, Addya S, Fortina P, Dasgupta A, Hyslop TM, Rhimm J, Bubendorf L, Nevalainen MT |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Aug 03, 2009 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Marja Nevalainen |
| E-mail(s) |
Marja.Nevalainen@jefferson.edu
|
| Phone |
215-503-9250
|
| Fax |
215-503-9245
|
| Organization name |
Thomas Jefferson University
|
| Department |
Cancer Biology
|
| Lab |
Nevalainen
|
| Street address |
233 S. 10th St
|
| City |
Philadelphia |
| State/province |
PA |
| ZIP/Postal code |
19107 |
| Country |
USA |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA118767 |
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