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| Status |
Public on Feb 17, 2026 |
| Title |
Vascular mitohormesis couples Mfn2 with improved systemic metabolism and healthspan |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
In this study, we hypothesized that mitochondrial dynamics in ECs orchestrates whole-body metabolic status. Here we report that genetic deficiency of endothelial Mfn2 (Mfn2iΔEC) in mice, originated a mitohormetic response that caused favorable vascular adaptations with regards to antioxidant defenses, mitochondrial fitness and lipid oxidation. As a result, Mfn2iΔEC mice exhibited improved metabolism, resistance to diet-induced obesity and delayed age-related decline. Our results reveal vascular mitohormesis as a novel operation mode influencing systemic energy metabolism and healthspan. These findings endorse the endothelium as a genuine metabolic organ and a potential target against metabolic and age-related deterioration.
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| Overall design |
RNAseq profiles of endothelial cells residing in the adipose tissue from Pdgfb-iCreERT2:Rpl22HA (endothelial RiboTag mice "WT" - 4 replicates) andPdgfb-iCreERT2:Mfn2iΔEC:Rpl22HA (Mfn2iΔEC:Rpl22HA) (endothelial RiboTag and endothelial Mfn2 deficient "KO" - 5 replicates) mice.
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| Contributor(s) |
Chivite I, Gómez-Valadés AG, Pozo M, Monelli E, Varela L, Ramírez S, Haddad-Tóvolli R, Beiroa D, Abot A, Osorio-Conles O, Valer JA, Obri AG, Milà-Guasch M, Villacampa P, Eyre E, Toledo M, Altirriba J, Remesar X, Zorzano A, Ventura F, Vidal J, Knauf C, Nogueiras R, Horvath TL, Graupera M, Claret M |
| Citation missing |
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| Submission date |
May 17, 2021 |
| Last update date |
Feb 17, 2026 |
| Contact name |
Jordi Altirriba |
| E-mail(s) |
altirriba@hotmail.com
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| Organization name |
Centre Médical Universitaire de Genève
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| Department |
Dpts de Médecine Interne et de Physiologie cellulaire et Métabolisme
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| Lab |
Laboratoire du Métabolisme
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| Street address |
Rue Michel-Servet 1
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| City |
Genève |
| ZIP/Postal code |
1211 |
| Country |
Switzerland |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA730519 |
| SRA |
SRP320114 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE174547_CPM-RibotagEndo.txt.gz |
240.8 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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