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| Status |
Public on May 07, 2021 |
| Title |
Parental exposure to environmental stress results in evolutionarily conserved intergenerational changes in offspring gene expression |
| Organisms |
Caenorhabditis briggsae; Caenorhabditis elegans; Caenorhabditis kamaaina; Caenorhabditis tropicalis |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
These data demonstrate that parental exposure to bacterial infection and osmotic stress intergenerational changes in offspring gene expression in C. elegans, C. kamaaina, C. briggsae and C. tropicalis. Many of these intergenerational changes in gene expression are observed in multiple species and this data identified >250 genes that exhibit intergenerational changes in expression in all species tested.
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| Overall design |
We exposed parents to multiple different bacterial pathogens (P. vranovensis, P. sp 15C5, Aeromonas sp. BIGb0469, and S. plymuthica) and osmotic stress and assayed effects on F1 and F3 gene expression.
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| Contributor(s) |
Burton N, Price J, Braukmann F, Miska E |
| Citation(s) |
34622777 |
| |
| Submission date |
May 06, 2021 |
| Last update date |
Nov 18, 2021 |
| Contact name |
Jonathan Lewis Price |
| Organization name |
University of Cambridge
|
| Department |
Biochemistry
|
| Lab |
Miska Lab
|
| Street address |
The Sanger Building Tennis Court Road
|
| City |
cambridge |
| ZIP/Postal code |
CB2 1QN |
| Country |
United Kingdom |
| |
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| Platforms (4)
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| GPL30091 |
DNBSEQ-G400 (Caenorhabditis elegans) |
| GPL30092 |
DNBSEQ-G400 (Caenorhabditis briggsae) |
| GPL30093 |
DNBSEQ-G400 (Caenorhabditis kamaaina) |
| GPL30094 |
DNBSEQ-G400 (Caenorhabditis tropicalis) |
|
| Samples (105)
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| Relations |
| BioProject |
PRJNA727816 |
| SRA |
SRP318752 |
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