|
| Status |
Public on Nov 22, 2021 |
| Title |
10X single-cell RNASeq profiling of immune infiltrate from mutant IDH1 ICC tumors treated with AG120 (mIDH1 inhibitor) or vehicle |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
AG120, mIDH1 inhibitor, has an immune-dependent mechanism. Single-cell RNA sequencing was used to profile the tumor microenvironment and the key immune subsets impacted by the inhibitor.
|
| |
|
| Overall design |
Profiling of immune infiltrate from mIDH1 ICC treated with AG120 or Vehicle.
|
| |
|
| Contributor(s) |
Kessler EA, Olander KE, Dubrot J |
| Citation(s) |
34848557 |
| |
| Submission date |
Apr 29, 2021 |
| Last update date |
Feb 21, 2022 |
| Contact name |
Kira Eileen Olander |
| E-mail(s) |
kolander@broadinstitute.org
|
| Phone |
6096106769
|
| Organization name |
Broad Institute
|
| Department |
Cancer Program
|
| Lab |
Manguso Lab
|
| Street address |
75 Ames St
|
| City |
Cambridge |
| State/province |
MA |
| ZIP/Postal code |
02140 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
|
| Samples (8)
|
|
| Relations |
| BioProject |
PRJNA726264 |
| SRA |
SRP317914 |
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