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Series GSE17306 Query DataSets for GSE17306
Status Public on Mar 26, 2010
Title Plasma cells from 52 patients with multiple myeloma: mRNA and miRNA expression profiling
Organism Homo sapiens
Experiment type Expression profiling by array
Non-coding RNA profiling by array
Summary We used microarray analyses of patient myeloma cells (n=52) to correlate individual miRNA expression profiles with GEP-based risk defined by mRNA expression profilesx as well as clinical features of the disease. Unlike for mRNAs, genome-wide elevation of miRNA expression patterns were significantly positively associated with a mRNA-based GEP-risk score (P <.01) and proliferation index (P <.05). Consistent with our observation of global deregulation of miRNA expression profiles, silencing EIF2C2/AGO2, a gene component of the mRNA-based high-risk signature and a master regulator of the genesis and functionality of all miRNAs, dramatically decreased viability in myeloma cell lines.
 
Overall design mRNA expression profiling: We performed protein-coding gene expression profiles of myeloma cells from newly diagnosed patients with different molecularly defined disease types.

miRNA expression profiling: We used microarray analyses of patient myeloma cells (n=52) to correlate individual miRNA expression profiles with GEP-based risk defined by mRNA expression profiles as well as clinical features of the disease.
 
Contributor(s) Shaughnessy J, Zhou Y, Stephens O, Chen L, Wu X, Barlogie B
Citation(s) 20385818
Submission date Jul 24, 2009
Last update date Mar 25, 2019
Contact name Yiming Zhou
E-mail(s) yzhou@uams.edu
Phone (501)296-1503 1413
Organization name Myeloma Institute for Research and Therapy
Street address 4301 West Markham St., Slot 776
City Little Rock
State/province AR
ZIP/Postal code 72205
Country USA
 
Platforms (2)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
GPL9081 Agilent-016436 Human miRNA Microarray 1.0 G4472A (miRNA ID version)
Samples (106)
GSM432969 Patient_01
GSM432970 Patient_02
GSM432971 Patient_03
Relations
BioProject PRJNA118969

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE17306_RAW.tar 272.7 Mb (http)(custom) TAR (of CEL, TXT)
Raw data provided as supplementary file
Processed data included within Sample table

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