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Series GSE1724 Query DataSets for GSE1724
Status Public on Nov 02, 2004
Title TGFbeta lung fibroblasts
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The response to a 4 hour treatment with TGFbeta (4 ng/ml) was evaluated in lung fibroblasts derived from three controls (normal periphery of resected tumor), open lung biopsies from three patients with idiopathic pulmonary fibrosis (usual interstitial pneumonia pattern on biopsy) and from three patients with fibrosing alveolitis associated with systemic sclerosis (fibrotic non specific interstitial pneumonia pattern on biopsy). Lung fibroblasts were grown to confluence in DMEM with 10% fetal calf serum. At confluence, lung fibroblasts were serum-deprived overnight, and exposed to either 4 ng/ml of activated TGF-ß1 (R&D Systems) or serum-free culture medium with 0.1% BSA for four hours.
Keywords: other
Contributor(s) Renzoni EA, Abraham DJ, Howat S, Shi-Wen X, Sestini P, Bou-Gharios G, Wells AU, Veeraraghavan S, Nicholson AG, Denton CP, Black CM, Welsh KI, du Bois RM
Citation(s) 15571627
Submission date Sep 02, 2004
Last update date Dec 13, 2018
Contact name Elisabetta Augusta Renzoni
Phone +44 (0) 207 3528121 ext 3364
Organization name Royal Brompton Hospital/Imperial College of Science, Technology and Medicine
Department Dept of Occupational and Environmental Medicine
Lab Interstitial Lung Disease Unit
Street address EKB, 1B Manresa Rd
City London
ZIP/Postal code SW3 6LR
Country United Kingdom
Platforms (1)
GPL8300 [HG_U95Av2] Affymetrix Human Genome U95 Version 2 Array
Samples (18)
GSM29911 Control 1 medium only
GSM29913 Control 1 TGFbeta-treated
GSM29915 Control 2 medium only
BioProject PRJNA90629

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