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Series GSE17160 Query DataSets for GSE17160
Status Public on Jul 05, 2011
Title Regulatory mechanisms of TSG-6 (TNF-alfa-induced protein-6: Tnfip6)-deficient and wild-type synovial fibroblasts
Organism Mus musculus
Experiment type Expression profiling by array
Summary BALB/c mice are susceptible to proteoglycan (PG) aggrecan-induced arthritis (PGIA), and the absence of TSG-6 further increases susceptibility and local inflammatory reactions, including neutrophil invasion into the joints. To gain insight into the mechanisms of TSG-6 action, synovial fibroblasts were isolated from wild-type and TSG-6-KO mice, cultured and exposed to various agents affecting either the TSG-6 expression and/or modify the intracellular function of TSG-6.
In the present microarray studies, we have identified differences in gene expression by fibroblasts isolated from wild-type or TSG-6-KO mice

Keywords: Genetic modification
Overall design In this study we compared the gene expression profile of 42 fibroblast cultures from mouse synovial samples. Fifteen samples were wild-type and 27 samples were TSG-6 knockout. In these two genotype groups fibroblasts were treated with TNFa, LPS, TSG-6, HA, or HA+TSG-6, and were compared to untreated samples in the same genotype group. We also compared the same treatments between KO and WT.
Contributor(s) Mikecz K, Glant TT, Laszlo A
Citation(s) 21566135
Submission date Jul 16, 2009
Last update date Feb 11, 2019
Contact name Tibor T Glant
Organization name Rush University Medical Center
Department Orthopedic Surgery
Lab Molecular Medicine
Street address 1735 West Harrison
City Chicago
State/province IL
ZIP/Postal code 60612
Country USA
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (42)
GSM429336 fibroblast, wild-type, untreated, biological replicate 1
GSM429337 fibroblast, wild-type, untreated, biological replicate 2
GSM429338 fibroblast, wild-type, untreated, biological replicate 3
BioProject PRJNA119657

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE17160_RAW.tar 152.0 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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